1452816-28-2

Upstream product

• 1452816-25-9 (2R,3S)-E-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhex-4-en-3-yl acetate 
• 1452816-24-8 (2R,3S)-E-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhex-4-en-3-ol 
• 1452816-23-7 (2R,3S)-E-6-(benzyloxy)-2,4-dimethylhex-4-ene-1,3-diol 
• 1452816-22-6 (R)-E-6-(benzyloxy)-1-hydroxy-2,4-dimethylhex-4-en-3-one 
• 443752-42-9 [4-(tert-butyl-diphenyl-silanyloxy)-1,3-dimethyl-2-oxo-butyl]-phosphonic acid diethyl ester 
• 95514-03-7 (R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate 
• 1452816-19-1 (R)-E-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)oxy]-2,4-dimethylhex-4-en-3-one 

Relevant academic research and scientific papers

Highly stereoselective syntheses of all 1,2,3-Me,OH,Me triads via asymmetric hydrogenation reactions

Iridium-catalyzed asymmetric hydrogenations of chiral alkenes were used to access four pivotal α,ω-functionalized chirons, that contain widely occurring stereochemical 1,2,3-Me,OH,Me motifs. A chiral analogue of Crabtree's catalyst was used in key hydrogenation steps to form these motifs with high stereochemical purities. An application of one of these chirons is illustrated here with a synthesis of (-)-invictolide. Copyright