145293-84-1

Upstream product

• 620-80-4 ethyl 2-benzylidene acetoacetate 
• 433733-19-8 2-benzyl-buta-2,3-dienoic acid ethyl ester 
• 142570-65-8 ethyl 2-diethylphosphono-3-phenylpropionate 
• 75-07-0 acetaldehyde 
• 858782-18-0 2-benzyl-3-hydroxy-butyric acid ethyl ester 

Downstream Products

• 5707-59-5 2-benzyl-crotonic acid 
• 1026652-72-1 (S)-2-[(S)-2-(3-Acetylsulfanyl-2-benzyl-butyrylamino)-hexanoylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 1026256-85-8 (S)-2-[(S)-2-(3-Acetylsulfanyl-2-benzyl-butyrylamino)-3-methyl-butyrylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 1026520-19-3 (3-Acetylsulfanyl-2-benzyl-butyrylamino)-acetic acid methyl ester 

Relevant academic research and scientific papers

[Pd(Ar-BIAN)(alkene)]-catalyzed highly chemo-, regio-, and stereoselective semihydrogenation of 1,2-allenyl phosphonates and related compounds

(Chemical Equation Presented) Often elusive, trisubstituted (Z)-1-alkenyl phosphonates can be prepared by the semihydrogenation of allenyl phosphonates in the presence of Pd complex 1. This reaction, which occurs in high yield with high chemo-, regio-, an

Exploration of Neutral Endopeptidase Active Site by a Series of New Thiol-Containing Inhibitors

With the aim of characterizing the active site of the neutral endopeptidase and especially its putative S1 subsite, two series of new thiol inhibitors designed to interact with the S1, S'1, and S'2 subsites of the enzyme have been synthesized.These molecules correspond to the general formula HSCH(R1)CH(R2)CONHCH(R3)COOH (series I) and HSCH(R1)CH(R2)CONHCH(R3)CONHCH(R4)COOH (series II).Due to the synthetic pathway used, these inhibitors were obtained as mixtures of four stereoisomers.HPLC separation of the stereoisomers of 17 HSCHCH(CH2Ph)CONHCH(CH3)COOH allowed the stereochemical dependence of the inhibitory potency to be determined.The most active isomer 17b (IC50 = 3.6 nM) is assumed to have the S,S,S stereochemistry as deduced from both NMR and HPLC data.Although none of the inhibitors obtained were significantly more active than thiorphan, HSCH2CH(CH2Ph)CONHCH2COOH (IC50 = 4 nM), which interacts only with the S'1 and S'2 subsites of NEP, their enhanced hydrophobicity is expected to improve their pharmacokinetic properties.All these compounds displayed low affinities for ACE (IC50S > 1 μM).The determination of the IC50S of two inhibitors of series II for NEP and for a mutated enzyme in which Arg102 was replaced by Glu102 allowed their mode of binding to the active site of NEP to be characterized.The R2 and R3 chains fit the S'1-S'2 subsites, while the R4 group is probably located outside the active site.Taken together these results indicate that the R1 chain of these inhibitors creates no additional stabilizing interactions with the active site of NEP.Two hypotheses may account for this: there is no hydrophophobic S1 subsite in NEP or the inhibitors have structures which are too constrained for optimized interactions with the active site.