433733-19-8

Upstream product

• 100-39-0 benzyl bromide 
• 75-36-5 acetyl chloride 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 15626-54-7 2-diazo-3-phenyl-propionic acid ethyl ester 
• 74-86-2 acetylene 
• 101308-40-1 ethyl 2-bromo-3-phenylpropionate 
• 26599-08-6 ethyl 3-phenyl-2-(triphenylphosphoranylidene)propanoate 
• 814-68-6 acryloyl chloride 

Downstream Products

• 528853-89-6 (2S,6S)-2,6-diphenyl-1-(toluene-4-sulfonyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid ethyl ester 
• 3007-91-8 ethyl-2-naphthoate 
• 82584-13-2 ethyl 1,4-dihydronapthalene-2-carboxylate 
• 1291073-36-3 6-benzyl-8-(2,4-dichlorobenzoyl)-7-methyl-2,3-dihydroimidazo[1,2-a]pyridin-5(1H)-one 
• 1291073-42-1 6-benzyl-8-(2-chlorobenzoyl)-7-methyl-2,3-dihydroimidazo[1,2-a]pyridin-5(1H)-one 
• 1291073-64-7 5-benzyl-6-methyl-1,2-dihydro-4H,7H-benzo[b]imidazo[1,2,3-ij][1,8]naphthyridine-4,7-dione 
• 1291073-56-7 7-benzyl-9-(2-chlorobenzoyl)-8-methyl-1,2,3,4-tetrahydropyrido[1,2-a]pyrimidin-6-one 
• 1291073-77-2 C₂₃H₂₀N₂O₂ 
• 1291073-46-5 6-benzyl-8-(2-chloro-4-(4-chlorophenyl)benzoyl)-7-methyl-2,3-dihydroimidazo[1,2-a]pyridin-5(1H)-one 
• 1291073-68-1 5-benzyl-10-(4-chlorophenoxy)-6-methyl-1,2-dihydro-4H,7H-benzo[b]imidazo[1,2,3-ij][1,8]naphthyridine-4,7-dione 
• 1291073-72-7 C₂₃H₁₉ClN₂O₂ 
• 1334397-61-3 ethyl 2-(2-methyl-3-tosyl-2,3-dihydrobenzo[d]oxazol-2-yl)-3-phenylpropanoate 
• 1334397-58-8 ethyl 2-(2-methylbenzo[d][1,3]dioxol-2-yl)-3-phenylpropanoate 

Relevant academic research and scientific papers

Iron-Catalyzed Aerobic Oxidation and Annulation Reaction of Pyridine and α-Substituted Allenoate toward Functionalized Indolizine

An iron-catalyzed reaction of pyridine and α-substituted allenoate has been disclosed. The present strategy incorporates the aerobic oxidation into annulation involving substituted allenoate, thus providing a new access to functionalized indolizine.

Organocatalyzed [2+2] Cycloaddition Reactions between Quinone Imine Ketals and Allenoates

A new cycloaddition reaction of quinone imine ketals (QIKs), which could be utilized to the construction of functionalized azaspirocyclics under mild conditions, is described. This transformation involved a [2+2] cycloaddition reaction between QIKs and allenoates catalyzed by DABCO, and then treatment with 1 N HCl in one-pot. The strategy could provide a practical route to access azetidine-fused spirohexadienones in good to excellent yields and with high E -selectivity.

Diastereoselective Synthesis of Tetracyclic Tetrahydroquinoline Derivative Enabled by Multicomponent Reaction of Isocyanide, Allenoate, and 2-Aminochalcone

We report here a multicomponent protocol to assemble several polycyclic dihydropyran-fused tetrahydroquinoline structures with excellent diastereoselectivity. This procedure employs simple feedstocks to accomplish a series of diverse structures, which is

Phosphine-Catalyzed [8 + 2]-Annulation of Heptafulvenes with Allenoates and Its Asymmetric Variant: Construction of Bicyclo[5.3.0]decane Scaffold

In this paper, a phosphine-catalyzed [8 + 2]-annulation of heptafulvene with allenoates has been achieved under mild conditions, giving functionalized bicyclo[5.3.0]decane derivatives in moderate to excellent yields. Using chiral phosphine as the catalyst, optically active products were obtained in moderate to high yields with excellent enantioselectivities.

Carbon-nitrogen bond cleavage of pyridine with two molecular substituted allenoates: Access to 2-arylpyrimidin-4(3: H)-one

A DABCO-catalyzed annulation reaction of pyridin-2-amine and substituted allenoates has been disclosed. This strategy allows for the ring-opening of a pyridine ring system and the formation of two new rings including a pyrimidinone ring and a benzene ring

Stereoselective Synthesis of Functionalized Benzooxazepino[5,4- a] isoindolone Derivatives via Cesium Carbonate Catalyzed Formal [5 + 2] Annulation of 2-(2-Hydroxyphenyl)isoindoline-1,3-dione with Allenoates

In this work, we present a strategy for the stereoselective synthesis of functionalized benzooxazepino[5,4-a]isoindolone derivatives via a Cs2CO3-catalyzed domino β-addition and γ-aldol reaction of 2-(2-hydroxyphenyl)isoindoline-1,3-dione derivatives with allenoates, which offers an avenue for a combination of the structural unity between benzooxazepine and isoindolone motifs in synthetically useful yields with high stereoselectivities under mild conditions. Remarkably, it is the first example of highly stereoselective Cs2CO3-catalyzed formal [5 + 2] annulation of 2-(2-hydroxyphenyl)isoindoline-1,3-dione with allenoates.

Unique Reactivity of α-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts

The efficient sulfinate-catalyzed intermolecular addition reaction of α-substituted allenyl sulfones and allenoates with Michael acceptors is highlighted. The sequence proceeds under mild conditions to provide a scalable and efficient access to versatile

Synthesis of Spirobidihydropyrazole through Double 1,3-Dipolar Cycloaddition of Nitrilimines with Allenoates

The double 1,3-dipolar cycloaddition of allenoates with nitrilimines has been achieved under mild reaction conditions, affording a variety of spirobidihydropyrazoles in moderate to excellent yields with excellent diastereoselectivities. The reaction diastereoselectively constructs double dihydropyrazole moieties and two chiral centers including a spiro carbon center.

Phosphine-Catalyzed Enantioselective [4 + 3] Annulation of Allenoates with C,N-Cyclic Azomethine Imines: Synthesis of Quinazoline-Based Tricyclic Heterocycles

With the use of a commercially available chiral phosphine as the catalyst, the first catalytic enantioselective [4 + 3] annulation of allenoates with C,N-cyclic azomethine imines is developed. The reaction works efficiently under mild reaction conditions to afford seven-membered ring-fused quinazoline-based tricyclic heterocycles in high yields with good to excellent diastereo- and enantioselectivities.

Synthesis of terminal allenes through copper-mediated cross-coupling of ethyne with N-tosylhydrazones or α-diazoesters

Ethyne is employed as coupling partner in coppermediated cross-coupling reactions with N-tosylhydrazones and α-diazoacetate, leading to the development of a new synthetic method for terminal allenes. With this novel coupling method, the terminal allenes w