145299-86-1 Usage
Description
(R)-1,1-Difluoro-3-phenyl-propan-2-ol, a chiral alcohol with the molecular formula C9H10F2O, features a fluorine atom attached to the second carbon of the propan-2-ol group and a phenyl group attached to the third carbon. Its unique structure and chiral nature contribute to its significance in various chemical applications.
Uses
Used in Pharmaceutical Industry:
(R)-1,1-Difluoro-3-phenyl-propan-2-ol is used as a chiral building block for the synthesis of pharmaceuticals. Its enantiomerically pure compounds are crucial in the development of drugs with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-1,1-Difluoro-3-phenyl-propan-2-ol serves as a chiral building block for the creation of enantiomerically pure agrochemicals, enhancing their performance and selectivity.
Used in Asymmetric Catalysis:
(R)-1,1-Difluoro-3-phenyl-propan-2-ol is utilized as a component in asymmetric catalysis, a technique that allows for the selective synthesis of one enantiomer over another, which is vital for producing biologically active compounds.
Used in Organometallic Chemistry:
(R)-1,1-Difluoro-3-phenyl-propan-2-ol also finds application as a ligand in organometallic chemistry, where it can influence the reactivity and selectivity of metal catalysts, leading to more efficient and selective chemical reactions.
Overall, (R)-1,1-Difluoro-3-phenyl-propan-2-ol is a versatile and valuable compound with significant applications across various industries, particularly in the synthesis of important chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 145299-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,2,9 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 145299-86:
(8*1)+(7*4)+(6*5)+(5*2)+(4*9)+(3*9)+(2*8)+(1*6)=161
161 % 10 = 1
So 145299-86-1 is a valid CAS Registry Number.
145299-86-1Relevant articles and documents
Preparation of and fluoroalkylation with (chlorodifluoromethyl)trimethylsilane, difluorobis(trimethylsilyl)methane, and 1,1,2,2-tetrafluoro-1,2-bis(trimethylsilyl)ethane
Yudin, Andrei K.,Prakash, G. K. Surya,Deffieux, Denis,Bradley, Michael,Bau, Robert,Olah, George A.
, p. 1572 - 1581 (2007/10/03)
CF2BrCl reacts with aluminum/N-methylpyrrolidinone in the presence of chlorotrimethylsilane to give Me3SiCF2Cl in high yield. Similarly, CF2Br2 gives Me3SiCF2Br with bromotrimethylsilane. Chlorodifluoromethylation of aldehydes using Me3SiCF2Cl and a catalytic amount of TBAF in polar solvents occurs at room temperature, providing difluoromethylated alcohols in two steps. Electroreduction of Me3SiCF2Cl in the presence of chlorotrimethylsilane gives Me3SiCF2SiMe3 (anion-derived product) and Me3SiCF2CF2SiMe3 (radical-derived product). Using THF/HMPA strongly favors the former, whereas THF/TDA-1 (tris(3,6-dioxaheptyl)amine) the latter. Me3SiCF2SiMe3 difluoromethylates aldehydes acting as a difluoromethylene dianion ('CF22-'/equivalent), whereas Me3SiCF2CF2SiMe3 acts at room temperature as an in situ source for the perfluorovinyl anion (due to β-elimination of fluorotrimethylsilane). However, at low temperature the elimination pathway is suppressed and tetrafluoroethylene dianion ('-CF2CF2-'/equivalent) behavior is observed. The structure of Me3SiCF2CF2SiMe3 was analyzed by X-ray diffraction. All of the studied fluoroalkylating reagents are moisture- and air-stable and can be readily obtained from a single convenient precursor (CF2BrCl).
