1453071-57-2Relevant academic research and scientific papers
Horner-Wadsworth-emmons reactions in THF: Effect of hydroperoxide species
Jarvis, Amanda G.,Wells, Elizabeth R.,Fairlamb, Ian J. S.
supporting information, p. 1493 - 1496 (2013/08/23)
Horner-Wadsworth-Emmons (HWE) reactions routinely employ tetrahydrofuran (THF) as the reaction solvent. In this paper we show that THF adducts (derived from THF-hydroperoxide species) of HWE phosphonate ester compounds are formed under microwave irradiation (i.e., under pressure), or in the presence of a reductant [e.g., P(OEt)3] in a conventionally heated reaction. Georg Thieme Verlag Stuttgart · New York.
