145325-42-4

Basic information

• Product Name: Benzoic acid, 4,4'-[1,5-pentanediylbis(oxy)]bis[3-methoxy-, dimethyl ester
• CAS NO: 145325-42-4
• Molecular Formula: C23H28O8
• Molecular Weight: 432.471
• Mol File: 145325-42-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4,4'-[1,5-pentanediylbis(oxy)]bis[3-methoxy-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4,4'-[1,5-pentanediylbis(oxy)]bis[3-methoxy-, dimethyl ester(145325-42-4)
• EPA Substance Registry System: Benzoic acid, 4,4'-[1,5-pentanediylbis(oxy)]bis[3-methoxy-, dimethyl ester(145325-42-4)

Safety Data

• Hazardous Substances Data: 145325-42-4(Hazardous Substances Data)

Upstream product

• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 628-77-3 1,5-diiodopentane 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 111-29-5 1 ,5-pentanediol 
• 3030-32-8 4,4’-(pentane-1,5-diylbis(oxy))bis(3-methoxybenzoic acid) 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 145325-45-7 1',5'-bis[2-methoxy-4-(methoxycarbonyl)-5-nitrophenoxy]pentane 
• 145325-51-5 1,1'-<<(pentane-1,5-diyl)dioxy>bis<(2-nitro-5-methoxy-1,4-phenylene)carbonyl>>bis 
• 145325-54-8 1,1'-<<(pentane-1,5-diyl)dioxy>bis<(2-amino-5-methoxy-1,4-phenylene)carbonyl>>bis 
• 260418-29-9 1,1'-[[(pentane-1,5-diyl)dioxy]-bis[(2-amino-N-allyloxycarbonyl-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S)-2-t-butyldimethylsilyloxymethyl-4-methylidene-2,3-dihydropyrrole] 
• 260418-27-7 1,1'-[[(pentane-1,5-diyl)dioxy]-bis[(2-amino-N-allyloxycarbonyl-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S,4R)-2-t-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine] 
• 260418-28-8 1,1'-[[(pentane-1,5-diyl)dioxy]-bis[(2-amino-N-allyloxycarbonyl-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S)-2-t-butyldimethylsilyloxymethyl-4-oxo-pyrrolidine] 
• 260418-25-5 (S,R)-((pentane-1,5-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((2S,4R)-2-(((tert-butyldimethylsllyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl) methanone) 
• 260418-30-2 1,1'-[[(pentane-1,5-diyl)dioxy]-bis[(2-amino-N-allyloxycarbonyl-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S)-2-hydroxymethyl-4-methylidene-2,3-dihydropyrrole] 
• 260418-26-6 1,1'-[[(pentane-1,5-diyl)dioxy]-bis[(2-amino-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S,4R)-2-t-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine] 

Relevant articles and documents

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The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.

Pyrrolobenzodiazepines

Compounds of the formulae Ia and Ib: wherein:A is CH2, or a single bond;R2 is selected from: R, OH, OR, CO2H, CO2R, COH, COR, SO2R, CN;R6, R7 and R9 are independently selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn;and R8 is selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn, where R is as defined above, or the compound is a dimer with each monomer being the same or different and being of formula Ia or Ib, where the R8 groups of the monomers form together a bridge having the formula -X-R'-X- linking the monomers, where R' is an alkylene chain containing from 3 to 12 carbon atoms, which chain may be interrupted by one or more hetero-atoms and/or aromatic rings and may contain one or more carbon-carbon double or triple bonds, and each X is independently selected from O, S, or N; except that in a compound of formula Ia when A is a single bond, then R2 is not CH=CH(CONH2) or CH=CH(CONMe2). Other related compounds are also disclosed.