260418-27-7Relevant articles and documents
Linker Length Modulates DNA Cross-Linking Reactivity and Cytotoxic Potency of C8/C8′ Ether-Linked C2-exo-Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Dimers
Gregson, Stephen J.,Howard, Philip W.,Gullick, Darren R.,Hamaguchi, Anzu,Corcoran, Kathryn E.,Brooks, Natalie A.,Hartley, John A.,Jenkins, Terence C.,Patel, Sejal,Guille, Matthew J.,Thurston, David E.
, p. 1161 - 1174 (2007/10/03)
A C2/C2′-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer 4b (DRG-16) with a C8-O(CH2)nO-C8′ diether linkage (n = 5) has been synthesized that shows markedly superior in vitro cytotoxic potency (e.g., > 3400-fold in IGRO