145325-47-9Relevant academic research and scientific papers
Synthesis of sequence-selective C8-linked pyrrolo[2,1-c][1,4]benzodiazepine DNA interstrand cross-linking agents
Thurston, David E.,Bose, D. Subhas,Thompson, Andrew S.,Howard, Philip W.,Leoni, Alberto,Croker, Stephen J.,Jenkins, Terrence C.,Neidle, Stephen,Hartley, John A.,Hurley, Laurence H.
, p. 8141 - 8147 (2007/10/03)
An efficient convergent synthesis of a homologous series of C8-linked pyrrolobenzodiazepine dimers with remarkable DNA interstrand cross-linking activity and potent in vitro cytotoxicity is reported. The 'amino thioacetal' cyclization procedure was used t
Facile and efficient synthesis of the dimers of DC-81 antitumor antibiotics
Kamal,Rao
, p. 4299 - 4302 (2007/10/02)
We report an improved, economical and versatile route to the dimers of DC-81 anti-tumour antibiotics. Particularly, the protection and deprotection steps in its synthesis and in the preparation of its precursors have been avoided. There is a significant i
