3030-31-7Relevant academic research and scientific papers
Synthesis of sequence-selective C8-linked pyrrolo[2,1-c][1,4]benzodiazepine DNA interstrand cross-linking agents
Thurston, David E.,Bose, D. Subhas,Thompson, Andrew S.,Howard, Philip W.,Leoni, Alberto,Croker, Stephen J.,Jenkins, Terrence C.,Neidle, Stephen,Hartley, John A.,Hurley, Laurence H.
, p. 8141 - 8147 (2007/10/03)
An efficient convergent synthesis of a homologous series of C8-linked pyrrolobenzodiazepine dimers with remarkable DNA interstrand cross-linking activity and potent in vitro cytotoxicity is reported. The 'amino thioacetal' cyclization procedure was used t
