145325-53-7Relevant academic research and scientific papers
An efficient catalytic deprotection of thioacetals employing bismuth triflate: Synthesis of pyrrolo[2,1-c] [1,4] benzodiazepines
Kamal, Ahmed,Reddy,Reddy, D. Rajasekhar
, p. 2857 - 2860 (2007/10/03)
A simple and efficient deprotection of thioacetals has been achieved by employing bismuth triflate. This method has been effectively employed in the preparation of DNA-binding pyrrolo[2,1-c] [1,4]benzodiazepine and its dimers.
A mild and efficient dethioacetalization employing FeCl3·6H2O: Synthesis of DNA-binding pyrrolo[2,1-c][1,4]benzodiazepine ring system and its dimers
Kamal,Laxman,Reddy
, p. 1476 - 1478 (2007/10/03)
A simple and efficient dethioacetalization has been carried out by employing FeCl3·6H2O under mild conditions. This method has been investigated for the synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine antitumour antibiotics via deprotective cyclization process.
Synthesis of sequence-selective C8-linked pyrrolo[2,1-c][1,4]benzodiazepine DNA interstrand cross-linking agents
Thurston, David E.,Bose, D. Subhas,Thompson, Andrew S.,Howard, Philip W.,Leoni, Alberto,Croker, Stephen J.,Jenkins, Terrence C.,Neidle, Stephen,Hartley, John A.,Hurley, Laurence H.
, p. 8141 - 8147 (2007/10/03)
An efficient convergent synthesis of a homologous series of C8-linked pyrrolobenzodiazepine dimers with remarkable DNA interstrand cross-linking activity and potent in vitro cytotoxicity is reported. The 'amino thioacetal' cyclization procedure was used t
Facile and efficient synthesis of the dimers of DC-81 antitumor antibiotics
Kamal,Rao
, p. 4299 - 4302 (2007/10/02)
We report an improved, economical and versatile route to the dimers of DC-81 anti-tumour antibiotics. Particularly, the protection and deprotection steps in its synthesis and in the preparation of its precursors have been avoided. There is a significant i
