14537-06-5

Upstream product

• 14645-35-3 methyl 3-fluoro-α-D-3-deoxy-arabinofuranoside 
• 98-88-4 benzoyl chloride 
• 14980-09-7 methyl 5-O-benzyl-3-fluoro-3-deoxy-α-D-arabino-furanoside 

Downstream Products

• 152711-02-9 C₁₉H₁₆BrFO₅ 
• 152785-09-6 1,5-Di-O-benzoyl-2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranose 
• 152711-05-2 Benzoic acid (2R,3S,5S)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 152711-06-3 Benzoic acid (2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 25526-93-6 alovudine 

Relevant academic research and scientific papers

Synthesis of 2',3'-dideoxy-3'-fluorothymidine using individual anomers of 1,5-di-O-benzoyl-2,3-dideoxy-3-fluoro-D-erythro-pentofuranose as glycosylating agents

A convenient preparation of α- and β-anomers of 1,5-di-O-benzoyl-2,3-dideoxy-3-fluoro-D-erythro-pentofuranose is described. Each anomer is studied as the glycosylating agent in the reaction with bis-trimethylsilylated thymine in the presence of trimethylsilyl triflate. Under optimum conditions, 2',3'-dideoxy-3'-fluorothymidine (FLT) and its α-anomer are isolated in 64 and 25% yields, respectively.