145371-72-8Relevant academic research and scientific papers
Synthesis of new pyrazolo[1,5-a]pyrimidines by reaction of β,γ-unsaturated γ-alkoxy-α-keto esters with N-unsubstituted 5-aminopyrazoles
Stepaniuk, Oleksandr O.,Matviienko, Vitalii O.,Kondratov, Ivan S.,Vitruk, Igor V.,Tolmachev, Andrei O.
supporting information, p. 925 - 930 (2013/05/09)
The reaction of β,γ-unsaturated γ-alkoxy-α-keto esters with N-unsubstituted 5-aminopyrazoles was investigated. The reaction proceeds with high regioselectivity and is considered as an effective- method for the preparation of new pyrazolo[1,5-a]pyrimidines bearing an ester function in the 7-position. The obtained drug-like compounds have a great potential for medicinal chemistry as they closely resemble the structure of several marketed pharmaceuticals. Georg Thieme Verlag Stuttgart - New York.
Unambiguous Structure Determination of Some Pyrazolopyrimidine Derivatives by Multinuclear NMR Spectroscopy
Chimichi, Stefano,Cosimelli, Barbara,Bruni, Fabrizio,Selleri, Silvia
, p. 1117 - 1121 (2007/10/02)
The condensation of 3(5)-aminopyrazole and 5-amino-3-phenylpyrazole with ethyl 2,4-dioxopentanoate and 2-ethoxymethylidene-3-oxobutyrate has been re-investigated.Contrary to previous reports, the former reaction gives rise to both regioisomeric pyrazolo1
