14538-56-8

Basic information

• Product Name: Piperazine phosphate
• Synonyms: PIPERAZINE PHOSPHATE;piperazinium dihydrogen phosphate;Einecs 238-572-0;Piperazine, phosphate (1:1);Piperazine Phosphate (200 mg);Piperazine Phosphate
• CAS NO: 14538-56-8
• Molecular Formula: C₄H₁₀N₂*2H₃O₄P
• Molecular Weight: 184.13
• EINECS: 238-572-0
• Product Categories: Piperidines, Piperidones, Piperazines
• Mol File: 14538-56-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 224-226 C
• Boiling Point: 468.9 °C at 760 mmHg
• Flash Point: 237.4 °C
• Appearance: Gray power
• Vapor Pressure: 4.36E-10mmHg at 25°C
• CAS DataBase Reference: Piperazine phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine phosphate(14538-56-8)
• EPA Substance Registry System: Piperazine phosphate(14538-56-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 14538-56-8(Hazardous Substances Data)

Usage

Uses

Piperazine Phosphate Monohydrate is used as an anthelmintic agent in the treatment of parasitic worm infections. Piperazine (P479900) derivatives are known to have high antiserotonin potency, antimicrobial activity, and potential anticancer activity in humans.

Brand name

Pincets (Marion Merrell Dow); Pinsirup (Marion Merrell Dow).

InChI:InChI=1/C4H10N2.H3O4P/c1-2-6-4-3-5-1;1-5(2,3)4/h5-6H,1-4H2;(H3,1,2,3,4)/p-2

Upstream product

• 110-85-0 piperazine 
• 86119-84-8 phosphoric acid 

Downstream Products

• 94159-17-8 melamine pyrophosphate 
• 66034-17-1 piperazine pyrophosphate 

Relevant articles and documents

Growth, nonlinear optical, thermal, dielectric and laser damage threshold studies of semiorganic crystal: Monohydrate piperazine hydrogen phosphate

Monohydrate piperazine hydrogen phosphate (MPHP), a semi organic nonlinear optical material has been synthesized and single crystals were grown from aqueous solution by slow evaporation technique. Single crystal X-ray diffraction study on grown crystal reveals that they belong to monoclinic crystal system with space group P21/c; (a = 6.39 A; b = 12.22 A; c = 11.16 A; β = 97.14°; V = 864 A3). The structural perfection of the grown crystal was analyzed by high-resolution X-ray diffraction (HRXRD) rocking curve measurements. FTIR spectrum confirms the presence of the functional groups in synthesized material. UV-Vis spectrum indicates that the crystal is transparent in the entire visible region with a lower cut off wavelength of 387 nm. The variation of dielectric properties of the grown crystal with respect to frequency has been investigated at different temperatures. Thermal analysis carried out on the MPHP crystal shows that the crystal is stable up to 135°C. Relative powder second harmonic generation efficiency tested by Kurtz-Perry powder technique, which was about 0.638 times that of Potassium dihydrogen phosphate.

Preparation method of pyrophosphate piperazine

The invention discloses a preparation method of pyrophosphate piperazine. The preparation method comprises the following steps: mixing ammonium dihydrogen phosphate and piperazine in an aqueous solution according to a mole ratio of 2:1, heating to remove ammonia, and dewatering for condensation to obtain the pyrophosphate piperazine. According to the preparation method, the shortcomings that conventional liquid phosphoric acid serving as a phosphorous source is difficult to transport and store are overcome; a reaction system is a weak-alkaline environment, so that erosion of the phosphoric acid serving as the phosphorous source to equipment is avoided; ammonia released during reaction can be used as protection atmosphere of the reaction system, and the whiteness value of a product meets the market requirement. Compared with a phosphoric acid-piperazine method, the preparation method has the advantage of saving the raw material cost by 10 to 15 percent.