145383-19-3

Upstream product

• 67-56-1 methanol 
• 7152-75-2 (Z)-2-phenyl-4-(4-nitrobenzylidene)-(4H)-1,3-oxazol-5-one 
• 93634-58-3 2-benzoylamino-3-(4-nitrophenyl)acrylic acid 
• 7152-75-2 4-(4-nitrobenzylidene)-2-phenyl-5(4H) oxazolone 
• 555-16-8 4-nitrobenzaldehdye 
• 495-69-2 Hippuric Acid 
• 100-66-3 methoxybenzene 

Downstream Products

• 105962-52-5 cis-4-p-nitrophenyl-3-benzamido-3-carbomethoxy-Δ¹-pyrazoline 
• 1394232-46-2 methyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate 
• 21742-96-1 4-(4-nitro-phenyl)-1⁽²⁾H-pyrazole-3-carboxylic acid methyl ester 
• 111016-50-3 4-(4-Nitro-phenyl)-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

Diastereoselective synthesis of 5-iminooxazolines and their subsequent transformation to α,α-disubstituted dipeptide esters: A formal [4+1] cycloaddition reaction of cyclohexyl isocyanide and Z-alkyl-α-benzoyl amino-acrylates

A novel atom economical diastereoselective synthesis of 5-iminooxazolines and their subsequent transformation to α,α-disubstituted dipeptide esters is described. Heating a mixture of cyclohexyl isocyanide and Z-α-benzoyl amino-acrylic acid alkyl esters un

The use of cyclohexyl isocyanide in the esterification of N-benzoyl α-amino acids derivatives

The N-benzoyl of α,β-dehydroamino acids that were obtained by condensation of N-benzoylglycine and an aldehyde, were esterified with an alcohol in high yield using cyclohexyl isocyanide to activate the carboxylic acid under neutral conditions.

One-pot process to Z-α-benzoylamino-acrylic acid methyl esters via potassium phosphate-catalyzed Erlenmeyer reaction

A practical and efficient two reaction sequence one-pot process for the synthesis of Z-α-benzoylamino-acrylic acid methyl esters was developed. The process involves a potassium phosphate-catalyzed Erlenmeyer reaction of aromatic aldehydes with hippuric acid followed by an oxazolone ring-opening methanolysis. This process afforded a good overall yield and an excellent product quality via a simple workup.

An usual behaviour of ethers in presence of azlactones under ultrasound irradiation to give esters

The phenomenon of ester formation from ethers and azlactones under sonolysis has been observed.

A new methodology for the synthesis of N-acylaminocinnamates

A new synthesis of biologically active N-protected amino acids (2) and amides (4) from 4-ylidene-5(4H)-oxazolones (1) is described.