1453905-07-1Relevant articles and documents
Light activation for the versatile and accurate kinetic analysis of disassembly of self-immolative spacers
Alouane, Ahmed,Labruere, Raphael,Le Saux, Thomas,Aujard, Isabelle,Dubruille, Sylvie,Schmidt, Frederic,Jullien, Ludovic
, p. 11717 - 11724 (2013)
Three procedures that rely on photoactivation are introduced to accurately analyze the disassembly kinetics of a collection of self-immolative spacer groups within the window 10-2-103 s. Our results are relevant for deriving quantitative structure-property relationships. In particular, we have been able to access 20 ms temporal resolution, which made possible the measurement of the shortest ever reported disassembly time for an activated self-immolative spacer. Quick as lightning! Accurate kinetic analysis of the disassembly of various self-immolative spacers in a 10 -2-103 s window was achieved. An epifluorescence setup allowed the measurement of the shortest time (20 ms) for a self-immolation event. Copyright