14545-93-8

Basic information

• Product Name: 17-oxo-5,6-epoxyandrostan-3-yl acetate
• CAS NO: 14545-93-8
• Molecular Formula: C₂₁H₃₀O₄
• Molecular Weight: 346.4605
• Mol File: 14545-93-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 452.6°C at 760 mmHg
• Flash Point: 196.7°C
• Density: 1.19g/cm³
• Vapor Pressure: 2.21E-08mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 17-oxo-5,6-epoxyandrostan-3-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 17-oxo-5,6-epoxyandrostan-3-yl acetate(14545-93-8)
• EPA Substance Registry System: 17-oxo-5,6-epoxyandrostan-3-yl acetate(14545-93-8)

Safety Data

• Hazardous Substances Data: 14545-93-8(Hazardous Substances Data)

Usage

Chemical class

Belongs to the class of androstane steroids.

Parent compound

Is a derivative of androsterone, a metabolite of testosterone.

Structural features

Contains an epoxy group at the 5,6 position and an oxo group at the 17 position on the androstane ring structure.

Additional functional group

Has an acetate group attached to the 3 position of the androstane ring.

Applications

Often used in research and pharmaceutical applications.

Purpose

Utilized for the development of androgenic and anabolic steroids.

Research focus

Involved in the study of hormone metabolism and signaling pathways in the human body.

Upstream product

• 50629-91-9 Acetic acid (3S,5R,6R,10R,13S)-6-chloro-5-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 853-23-6 prasterone acetate 
• 64-19-7 acetic acid 

Downstream Products

• 853-23-6 3β-acetoxy-5-androsten-17-one 
• 41853-36-5 3β-Acetoxy-5α-hydroxyandrostan-17-on 
• 853-23-6 prasterone acetate 

Relevant articles and documents

Recycling method of positional isomer in preparation of 3beta-acetoxy-5alpha-chloro-6beta-hydroxyandrost-17-one

The invention discloses a recycling method for forming 3beta-acetoxyandrost-5-en-17-one by performing a cyclization elimination reaction by utilizing solid waste 3beta-acetoxy-6beta-chloro-5alpha-hydroxyandrost-17-one obtained in the process of an addition reaction of preparing 3beta-acetoxy-5alpha-chloro-6beta-hydroxyandrost-17-one from 3beta-acetyloxyandrost-5-en-17-one as a raw material, and performing a reduction elimination reaction. The method provided by the invention can effectively recover and reuse the by-product obtained in the preparation process of the 3beta-acetoxy-5alpha-chloro-6beta-hydroxyandrost-17-one, and the synthetic method is simple and convenient to operate, has mild reaction conditions, is environmentally friendly, and reduces the production costs of preparing the3beta-acetoxy-5alpha-chloro-6beta-hydroxyandrost-17-one from the 3beta-acetyloxyandrost-5-en-17-one.

The Stereochemistry of Epoxidation of Δ5-Steroids with Sodium Perborate and Potassium Permanganate

Sodium perborate, with potassium permanganate as a catalyst, has been shown to be a novel reagent for the epoxidation of steroidal 5-enes with the attack occurring predominantly on the β-face.