145452-06-8Relevant academic research and scientific papers
De novo design, synthesis, and X-ray crystal structures of pyrrolinone-based β-strand peptidomimetics
Smith III, Amos B.,Guzman, Mark C.,Sprengeler, Paul A.,Keenan, Terence P.,Holcomb, Ryan C.,Wood, John L.,Carroll, Patrick J.,Hirschmann, Ralph
, p. 9947 - 9962 (2007/10/02)
The de novo design and synthesis of a novel non-peptide scaffolding for β-strand/sheet mimics are described. The scaffold consists of repeating 3,5,5-trisubstituted pyrrolinone (enaminone) units punctuated with appropriate amino acid side chains. The iter
