145452-65-9

Upstream product

• 100-39-0 benzyl bromide 
• 145476-98-8 ethyl -α,α-difluoro-β-hydroxy-4-oxo-2-azetidinepropanoate 
• 145452-62-6 -1-<3-(4-oxo-2-azetidinyl)-2,2-difluoro-3-hydroxy-1-oxopropyl>pyrrolidine 
• 145452-63-7 <2R-<2α,3α(S*)>>-<2-<<2-<1,1-difluoro-2-oxo-2-(1-pyrrolidinyl)ethyl>tetrahydro-5-oxo-3-furanyl>amino>-1-methyl-2-oxoethyl>carbamic acid, 1,1-dimethylethyl ester 
• 145452-64-8 (2R-cis)-N-<(1,1-dimethylethoxy)carbonyl>-L-valyl-N-<2-<1,1-difluoro-2-oxo-2-(1-pyrrolidinyl)ethyl>tetrahydro-5-oxo-3-furanyl>-L-alaninimide 
• 145452-51-3 ethyl -1-<(1,1-dimethylethyl)dimethylsilyl>-α,α-difluoro-β-hydroxy-4-oxo-2-azetidinepropanoate 

Downstream Products

• 145452-66-0 (S)-N-<(1,1-dimethylethoxy)carbonyl>-L-valyl-N-<3,3-difluoro-2,4-dioxo-1-<2-oxo-2-(phenylmethoxy)ethyl>-4-(1-pyrrolidinyl)butyl>-L-alaninimide 

Relevant academic research and scientific papers

Synthesis of a Peptidyl Difluoro Ketone Bearing the Aspartic Acid Side Chain: An Inhibitor of Interleukine-1β Converting Enzyme

The synthesis of the peptidyl difluoro ketone 1, an inhibitor of interleukin-1β converting enzyme (ICE), was accomplished by a route beginning with the reaction of BrZnCF2CO2Et (2) with (2S)-1-(tert-butyldimethylsilyl)-4-oxo-2-azetidinecarboxaldehyde (3)