Synthesis of a Peptidyl Difluoro Ketone Bearing the Aspartic Acid Side Chain: An Inhibitor of Interleukine-1β Converting Enzyme

Article abstract of DOI:10.1021/jo00052a054

The synthesis of the peptidyl difluoro ketone 1, an inhibitor of interleukin-1β converting enzyme (ICE), was accomplished by a route beginning with the reaction of BrZnCF2CO2Et (2) with (2S)-1-(tert-butyldimethylsilyl)-4-oxo-2-azetidinecarboxaldehyde (3)