1454575-10-0Relevant academic research and scientific papers
Fluoride E ring camptothecin analogs and their use as medicaments
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Paragraph 0085; 0086; 0109; 0110; 0111; 0112, (2016/10/07)
The invention relates to the technical field of medicines and in particular relates to fluoro-substituted E cyclocamptothecin analogues and use thereof as a drug. The structure of the compounds is shown in a formula I; and the compounds exist in forms of raceme, diastereoisomer as well as any mixture of the forms or medical salts thereof. The compounds disclosed by the invention have the effect of restraining the activity of the topoisomerase I and can be used for preparing anti-tumor drugs and also can be used for preparing drugs for preventing virus and fungal infection.
Synthesis and biological activities of fluorinated 10-hydroxycamptothecin and SN38
Wu, Yuelin,Zhu, Lingjian,Sheng, Chunquan,Yao, Jianzhong,Miao, Zhenyuan,Zhang, Wannian,Wei, Yunyang,Shi, Ruofu
, p. 48 - 51 (2014/01/06)
It is an important strategy for fluorine substitution in drug design because of its small size and high electronegativity. Fluorinated 10-hydroxycamptothecin and SN 38 were prepared and screened for antiproliferative activities. Among them, fluorinated co
