14548-51-7

Basic information

• Product Name: 7-Bromo-3,4-dihydro-1H-quinolin-2-one
• Synonyms: 7-Bromo-3,4-dihydro-1H-quinolin-2-one;7-broMo-3,4-dihydroquinolin-2(1H)-one;7-BROMO-1,2,3,4-TETRAHYDRO-2-QUINOLINONE
• CAS NO: 14548-51-7
• Molecular Formula: C9H8BrNO
• Molecular Weight: 226.06992
• Mol File: 14548-51-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 359.1 °C at 760 mmHg
• Flash Point: 171 °C
• Appearance: /
• Density: 1.559 g/cm³
• Vapor Pressure: 2.43E-05mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.08±0.20(Predicted)
• CAS DataBase Reference: 7-Bromo-3,4-dihydro-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-3,4-dihydro-1H-quinolin-2-one(14548-51-7)
• EPA Substance Registry System: 7-Bromo-3,4-dihydro-1H-quinolin-2-one(14548-51-7)

Safety Data

• Hazardous Substances Data: 14548-51-7(Hazardous Substances Data)

Usage

General Description

7-Bromo-3,4-dihydro-1H-quinolin-2-one is a chemical compound that belongs to the class of quinolin-2-one derivatives. It is a heterocyclic compound with a bromine atom attached to the 7th position of the quinoline ring. 7-Bromo-3,4-dihydro-1H-quinolin-2-one has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceuticals and agrochemicals. It may also be used as a building block in organic synthesis to create more complex molecules. Additionally, it has been studied for its potential biological activities and may have implications in the treatment of various diseases. Overall, 7-Bromo-3,4-dihydro-1H-quinolin-2-one is a valuable chemical compound with versatile applications in various industries.

InChI:InChI=1/C9H8BrNO/c10-7-3-1-6-2-4-9(12)11-8(6)5-7/h1,3,5H,2,4H2,(H,11,12)

Upstream product

• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 14548-39-1 6-bromoindan-1-one 
• 501-52-0 3-Phenylpropionic acid 

Downstream Products

• 903557-01-7 2-oxo-1,2,3,4-tetrahydroquinoline-7-carbonitrile 
• 1579950-30-3 7-{[3-(trifluoromethyl)phenyl]amino}-3,4-dihydroquinoline-2(1H)-one 
• 114744-51-3 7-bromo-1,2,3,4-tetrahydroquinoline 
• 1187932-64-4 tert-butyl 7-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 
• 99465-10-8 7-bromo-1,2-dihydroquinolin-2-one 

Relevant articles and documents

Visible-Light Induced C(sp2)?H Amidation with an Aryl–Alkyl σ-Bond Relocation via Redox-Neutral Radical–Polar Crossover

We report an approach for the intramolecular C(sp2)?H amidation of N-acyloxyamides under photoredox conditions to produce δ-benzolactams with an aryl-alkyl σ-bond relocation. Computational studies on the designed reductive single electron transfer strategy led us to identify N-[3,5-bis(trifluoromethyl)benzoyl] group as the most effective amidyl radical precursor. Upon the formation of an azaspirocyclic radical intermediate by the selective ipso-addition with outcompeting an ortho-attack, radical–polar crossover was then rationalized to lead to the rearomative ring-expansion with preferential C?C bond migration.

Structure-guided rescaffolding of selective antagonists of BCL-X L

Because of the promise of BCL-2 antagonists in combating chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL), interest in additional selective antagonists of antiapoptotic proteins has grown. Beginning with a series of selective, potent BC