145489-94-7Relevant academic research and scientific papers
Acetic acid promoted metal-free aerobic carbon-carbon bond forming reactions at α-position of tertiary amines
Ueda, Hirofumi,Yoshida, Kei,Tokuyama, Hidetoshi
, p. 4194 - 4197 (2014)
The oxidative functionalization of the benzylic C-H bonds in tetrahydroisoquinolines and tetrahydro-β-carboline derivatives was investigated. C-C bond forming reactions proceeded with a range of nucleophiles (nitroalkane, enol silyl ether, indole, allylstannane, and tetrabutylammonium cyanide) under metal-free conditions and an oxygen atmosphere. Acetic acid caused a significant acceleration effect.
FeCl3-Catalyzed oxidative allylation of sp2 and sp3 C-H bond adjacent to a nitrogen atom: Easy access to homoallyl tertiary amines
Kumaraswamy, Gullapalli,Murthy, Akula Narayana,Pitchaiah, Arigala
supporting information; experimental part, p. 3916 - 3919 (2010/07/05)
Figure presented Oxidative allylation to sp2- and sp 3-carbon attached to the nitrogen atom was accomplished. The α-allylation of tertiary amines was catalyzed by easily available hydrated iron(III) chloride in combination with air or aqueous tBuOOH. Remarkably, N-allyl- and N-propagyl-tethered tertiary amines were also allylated through this protocol.
