1455-20-5

Basic information

• Product Name: 2-N-BUTYLTHIOPHENE
• Synonyms: 2-N-BUTYLTHIOPHENE;2-BUTYLTHIOPHENE;2-THIENYLBUTANE;THENYLPROPANE;Thiophene, 2-butyl-;2-N-BUTYLTHIOPHENE, 98+%;2-n-Butylthiophene, 97+%
• CAS NO: 1455-20-5
• Molecular Formula: C₈H₁₂S
• Molecular Weight: 140.25
• EINECS: 215-935-1
• Mol File: 1455-20-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: -56.9°C (estimate)
• Boiling Point: 181-182°C
• Flash Point: 35°C
• Appearance: /
• Density: 0,97 g/cm3
• Vapor Pressure: 1.18mmHg at 25°C
• Refractive Index: 1.5020
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Soluble in acetone and DMSO.
• BRN: 107046
• CAS DataBase Reference: 2-N-BUTYLTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-N-BUTYLTHIOPHENE(1455-20-5)
• EPA Substance Registry System: 2-N-BUTYLTHIOPHENE(1455-20-5)

Safety Data

• Hazard Codes: Xn
• Statements: 10-22
• Safety Statements: 16
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 1455-20-5(Hazardous Substances Data)

Usage

Uses

2-n-Butylthiophene is an inhibitor of DMH-induced aberrant crypt formation. It is used as a Glutathione S-transferase inducer. It Inhibits tumorigenesis in vivo. It is used as a primary and secondary intermediate.

InChI:InChI=1/C8H12S/c1-2-3-5-8-6-4-7-9-8/h4,6-7H,2-3,5H2,1H3

Upstream product

• 188290-36-0 thiophene 
• 109-65-9 1-bromo-butane 
• 106-99-0 buta-1,3-diene 
• 59594-93-3 4-(thiophen-2-yl)butan-2-one 
• 1003-09-4 2-bromothiophene 
• 693-03-8 n-butyl magnesium bromide 
• 3141-27-3 2,5-dibromothiophen 
• 111-65-9 octane 
• 138767-12-1 α-Propylthiophenmethanol 
• 4426-47-5 butylboronic acid 
• 110-52-1 1,4-dibromo-butane 
• 5333-83-5 2-butyrylthiophene 
• 3437-95-4 2-Iodothiophene 
• 542-69-8 1-iodo-butane 

Downstream Products

• 98954-25-7 5-n-butylthiophene-2-carbaldehyde 
• 128619-83-0 2-bromo-5-n-butyl-thiophene 
• 64964-19-8 5-Butyl-2-thiophencarbonsaeurechlorid 
• 33566-59-5 methyl 4-oxo-dodecanoate 
• 1448448-98-3 2-(2-(5-n-butylthiophen-2-yl)-6-methylphenyl)quinoline 
• 1601461-97-5 2-n-butyl-4-(2-fluorophenyl)thiophene 
• 1601461-99-7 4-(4-bromo-2-methylphenyl)-2-n-butylthiophene 
• 1601462-00-3 ethyl 4-(5-n-butylthiophen-3-yl)benzoate 
• 1601462-01-4 2-n-butyl-4-(4-nitrophenyl)thiophene 
• 1601462-02-5 2-n-butyl-4-(4-(trifluoromethyl)phenyl)thiophene 
• 1601462-03-6 5-n-butyl-3,3'-bithiophene 
• 121819-86-1 2-n-butyl-4-phenylthiophene 
• 1522464-89-6 3-(5-butylthiophen-2-yl)-N-phenylisonicotinamide 
• 1522465-09-3 2-(5-butylthiophen-2-yl)-N-phenylquinoline-3-carboxamide 

Relevant articles and documents

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Ligand assessment for the suzuki-miyaura cross coupling reaction of aryl and heteroaryl bromides with n-butylboronic acid. The advantages of buchwald's s-phos

An investigation of biarylphosphine ligands for the Suzuki-Miyaura cross coupling reaction of aryl and heteroaryl bromides with n-butylboronic acid is presented. The results obtained on ligand modification and aryl as well as heteroaryl bromides variation represent a significant improvement in the state of the art of alkylboronic acid cross coupling methodology.

Palladium-catalyzed regioselective allylation of five-membered heteroarenes with allyltributylstannane

Palladium-catalyzed allylation reactions of 2-(chloromethyl)thiophenes, 2-(chloromethyl)furans, and N-protected 2-(chloromethyl)-1H-pyrroles with allyltributylstannane were described in this study. This type of allylation reaction regioselectively occurred on the heteroarene rings to produce allylated dearomatization products or allylated heteroarenes with satisfactory yields.