1455035-98-9

Upstream product

• 40296-46-6 ethyl 4,6-dichloronicotinate 
• 1391740-89-8 ethyl 6-chloro-4-[(4-methoxyphenyl)methylamino]pyridine-3-carboxylate 
• 380626-81-3 ethyl 4-amino-6-chloropyridine-3-carboxylate 
• 846036-96-2 (4-amino-6-chloropyridin-3-yl)methanol 
• 1001756-21-3 4-amino-6-chloropyridine-3-carboxaldehyde 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 170098-98-3 1-bromo-4-fluoro-2-methyl-5-nitro-benzene 
• 945244-29-1 5-bromo-2-fluoro-4-methylaniline 
• 1012880-11-3 2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1455035-96-7 7-chloro-2-methyl[1,6]naphthyridin-3-yl trifluoromethanesulfonate 
• 1455035-91-2 7-chloro-2-methyl-[1,6]naphthyridin-3-ol 

Downstream Products

• 1455038-64-8 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea 
• 1455038-10-4 prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate 
• 1455038-18-2 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(3,3,3-trifluoropropyl)urea 
• 1455036-17-5 3-(5-amino-4-fluoro-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine 
• 1455036-26-6 3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine 
• 1455037-49-6 1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)-4-methylphenyl)urea 
• 1455036-70-0 prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate 
• 1455031-68-1 N-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-N'-[(2S)-2-hydroxy-3,3-dimethylbutyl]-urea 
• 1455031-70-5 1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[(2R)-2-hydroxy-3,3-dimethyl-butyl]urea 
• 1455031-66-9 1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea 
• 1455036-94-8 prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate 
• 1455030-79-1 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea 

Relevant academic research and scientific papers

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3- d ]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells

The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with activation typically mediated through cell surface receptors. The kinase inhibitors vemurafenib and dabrafenib, which target oncogenic BRAF V600E, have shown significant clinical efficac

RAF INHIBITOR COMPOUNDS

This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.