145508-90-3Relevant academic research and scientific papers
Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: Excellent substrates for NAD(P)H:quinone oxidoreductase 1
Newsome, Jeffery J.,Hassani, Mary,Swann, Elizabeth,Bibby, Jane M.,Beall, Howard D.,Moody, Christopher J.
, p. 2999 - 3009 (2013)
A series of heterocyclic quinones based on benzofuran, benzothiophene, indazole and benzisoxazole has been synthesized, and evaluated for their ability to function as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumor cells. Overall, the quinones are excellent substrates for NQO1, approaching the reduction rates observed for menadione.
Amino sulfonyl compound, preparation method and uses thereof
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Paragraph 0189; 0190, (2016/12/01)
The present invention relates to a new amino sulfonyl compound represented by a general formula I, or a tautomer, an enantiomer, a racemate or a pharmaceutically acceptable salt thereof, a preparation method, a pharmaceutical composition, and uses thereof, wherein the compound can be used for treatment of epilepsy, convulsion, obesity, and the like. The general formula I is defined in the specification.
Copper-catalyzed cyclization of Z-oximes into 3-methyl-1,2-benzisoxazoles
Udd, Sandra,Jokela, Reija,Franzén, Robert,Tois, Jan
supporting information; experimental part, p. 1030 - 1033 (2010/04/02)
A practical and effective room temperature copper-catalyzed cyclization of Z-oximes is developed. 3-Methyl-1,2-benzisoxazoles are obtained in 58-79% yields. Also, the Z-selective synthesis of o-bromo acetophenone oximes is presented for the first time.
