14554-17-7

Upstream product

• 35274-92-1 3-(benzylamino)-1-phenylpropan-1-one hydrochloride 
• 50-00-0 formaldehyd 
• 3287-99-8 benzylamine hydrochloride 
• 98-86-2 acetophenone 
• 27152-63-2 3-(N-Benzylamino)-1-phenylpropan-1-on 
• 2298-49-9 N-methyl-3-oxo-N-(3-oxo-3-phenylpropyl)-3-phenylpropan-1-aminium chloride 
• 100-46-9 benzylamine 

Downstream Products

• 31314-44-0 1-(2-hydroxyethyl)-4,4-diphenylpiperidine 
• 35985-34-3 1-(3-hydroxypropyl)-4,4-diphenylpiperidine 
• 35879-51-7 1-acetonyl-4,4-diphenylpiperidine 
• 34273-01-3 4,4-diphenylpiperidine 
• 31314-37-1 1-ethyl-4,4-diphenylpiperidine 
• 91075-60-4 1-Pivaloyl-4,4-diphenylpiperidin 
• 91075-45-5 1-n-butyl-4,4-diphenylpiperidine 
• 91075-47-7 1-(2-acetoethyl)-4,4-diphenylpiperidine 
• 40105-95-1 4,4-diphenyl-N-benzylpiperidine 

Relevant academic research and scientific papers

Asymmetric Hydrogenation of β-Secondary Amino Ketones Catalyzed by a Ruthenocenyl Phosphino-oxazoline-ruthenium Complex (RuPHOX-Ru): The Synthesis of γ-Secondary Amino Alcohols

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX-Ru) was applied successfully to the asymmetric hydrogenation of β-secondary amino ketones, directly affording the corresponding chiral γ-secondary amino alcohols in up to 99% yield and with 99% ee. Reaction with β-(benzylamino)-1-phenylpropan-1-one could be performed on a gram-scale with a relatively low catalyst loading (up to 2000 S/C). The resulting hydrogenated product could be used for the synthesis of synthetically useful compounds.

Mannich bases as synthetic intermediates: Alkylation of amines and diamines with bis-ketonic Mannich bases

The bis-ketonic Mannich base, N,N-bis(β-benzoylethyl)methylamine hydrochloride (1) reacts with primary arylamines and diamines to give ketonic sec-arylamines 3a-e and 4. The piperidines 7a-c were obtained from 1 and primary alkylamines, whereas the 1,4-diazepine derivative 10 was obtained from 1 and ethylenediamine. Treatment of the bis-base l,4-di[β-(N-morpholino) propionyl]benzene bis(hydrochloride) (11) with primary arylamines gave the corresponding bis-(sec-arylamines) 12a - b, whereas its reaction with o-phenylenediamine afforded the bis[1,5-benzodiazepine] ring system 14. The synthesis of the diazacyclophane ring system 15 has been achieved by treating 11 with piperazine. Attempted synthesis of 4-aza-[7]-paracyclophane (16) from 11 and benzylamine led to 17. The reaction of 1 or 11 with phenylhydrazine gave the 2-pyrazolines 18 and 19. Treatment of 3 or 4 with phenylhydrazine and formaldehyde afforded the 2H-1,2,4-triazepines 20a-c and the bis[2H-1,2,4-triazepine] ring system 21.

2-Substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines and related compounds

2-Substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines having anti-arrhythmic activity are described herein. The subject compounds can be prepared by reduction of the corresponding 2-Substituted-9-phenyl-2,3-dihydro-1H-indeno[2,1-c]pyrid

1-(Substituted-aminoalkyl)-3-benzoyl-4-hydroxy-4-phenylpiperidines and related compounds

1-(Substituted-aminoalkyl)-3-benzoyl-4-hydroxy-4-phenylpiperidines and related compounds having anti-arrhythmic activity are described herein. The 3-benzoyl compounds can be prepared by condensing the appropriate diamine with acetophenone and formaldehyde