35274-92-1

Upstream product

• 50-00-0 formaldehyd 
• 3287-99-8 benzylamine hydrochloride 
• 98-86-2 acetophenone 

Downstream Products

• 34597-73-4 3-(Benzylamino)-1-phenyl-1-propanol 
• 181474-62-4 5-[Benzyl-(3-hydroxy-3-phenyl-propyl)-amino]-4-chloro-2-methyl-2H-pyridazin-3-one 
• 181474-66-8 5-[Benzyl-(3-chloro-3-phenyl-propyl)-amino]-4-chloro-2-methyl-2H-pyridazin-3-one 
• 71371-93-2 ((2S,3S)-3-Hydroxy-2,3-diphenyl-pyrrolidin-1-yl)-phenyl-methanone 
• 71371-93-2 ((2S,3R)-3-Hydroxy-2,3-diphenyl-pyrrolidin-1-yl)-phenyl-methanone 
• 474925-47-8 1-benzyl-2-oxo-4-phenyl-piperidine-3-carboxylic acid methyl ester 
• 71371-89-6 N-Benzoyl-N-benzyl-β-aminopropiophenon 
• 95886-45-6 3-Benzyl-2-chloro-6-phenyl-3,4-dihydro-[1,3,2]oxazaphosphinine 2-oxide 
• 14554-17-7 (1-benzyl-4c-hydroxy-4t-phenyl-[3r]piperidyl)-phenyl ketone 

Relevant academic research and scientific papers

Practical synthesis of enantiopure γ-amino alcohols by rhodium-catalyzed asymmetric hydrogenation of β-secondary-amino ketones

(Chemical Equation Presented) Another way to antidepressants: A series of β-secondary-amino ketone hydrochlorides (e.g. 1) were hydrogenated with remarkably high enantioselectivities by using a Rh complex containing P-chiral bisphospholane 2. These results establish a short and practical means for the synthesis of enantiopure N-monosubstituted γ-amino alcohols (e.g. 3), which are key intermediates in the synthesis of important antidepressants. (nbd = norbornadiene; TON = turnover number).