14558-49-7

Usage

Uses

Used in Organic Chemistry:
1,3-Oxazinane is used as a ring structure in the synthesis of complex organic compounds, contributing to the creation of a wide range of chemical products.
Used in Chemical Synthesis:
Due to its unique molecular structure, 1,3-oxazinane is employed as a versatile building block in chemical synthesis, allowing for the development of new compounds with diverse properties.
Used in Pharmaceutical Industry:
1,3-Oxazinane is used as a key intermediate in the production of certain pharmaceuticals, leveraging its stability and reactivity to facilitate the synthesis of drug molecules.
Used in Material Science:
1,3-oxazinane's polar and nonpolar characteristics make 1,3-oxazinane a valuable component in the development of new materials with specific properties, such as improved stability or reactivity.

InChI:InChI=1/C4H9NO/c1-2-5-4-6-3-1/h5H,1-4H2

Upstream product

• 50-00-0 formaldehyd 
• 156-87-6 propan-1-ol-3-amine 
• 63489-63-4 bis(1,3-oxazinan-3-yl)methane 

Downstream Products

• 66127-22-8 3-[3-(3-phenoxymethyl-phenyl)-propyl]-[1,3]oxazinane 
• 19199-33-8 3-[3-(4-chloro-phenyl)-acryloyl]-[1,3]oxazinane 
• 17077-43-9 3-(4-phenyl-but-3-enoyl)-[1,3]oxazinane 
• 38943-54-3 3-(3,4,5-trimethoxy-benzoyl)-[1,3]oxazinane 
• 19201-99-1 3-benzoyl-[1,3]oxazinane 
• 19202-06-3 3-(4-chloro-benzoyl)-[1,3]oxazinane 
• 19199-22-5 3-(3-phenyl-acryloyl)-[1,3]oxazinane 
• 19202-20-1 3-[(4-chloro-phenyl)-acetyl]-[1,3]oxazinane 
• 1968-05-4 3,3'-diindolylmethane 
• 103174-73-8 diethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 16502-01-5 tetrahydrobetacarboline 
• 1149-23-1 diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 51-17-2 benzoimidazole 
• 95-16-9 1,3-Benzothiazole 

Relevant academic research and scientific papers

FUNGICIDAL PENFLUFEN MIXTURES

The invention relates to mixtures comprising penflufen, to the use of these mixtures for protecting industrial materials and to a method for treating industrial materials with the penflufen mixtures.

Cinnamoyl inhibitors of tissue transglutaminase

(Figure Presented) Transglutaminases (TGases) catalyze the intermolecular cross-linking of certain proteins and tissue TGases (TG2) are involved in diverse biological processes. Unregulated, high TGase activities have been implicated in several physiological disorders, but few reversible inhibitors of TG2 have been reported. Herein, we report the synthesis of a series of novel trans-cinammoyl derivatives, discovered to be potent inhibitors of guinea pig liver transglutaminase. The most effective inhibitors evaluated can be sorted into two subclasses: substituted cinnamoyl benzotriazolyl amides and the 3-(substituted cinnamoyl)pyridines, referred to more commonly as azachalcones. Kinetic evaluation of both of these subclasses revealed that they display reversible inhibition and are competitive with acyl donor TGase substrates at IC50 values as low as 18 μM. An analysis of structure - activity relationships within these series of inhibitors permitted the identification of potentially important binding interactions. Further testing of some of the most potent inhibitors demonstrated their selectivity for TG2 and their potential for further development.

CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE

A compound of Formula, (I) or Formula: (II)

Bromonitrothienyldioxanes

The invention relates to novel 5-bromo-5-nitro-2-thienyl-1,3-dioxanes of the formula (I) in which R1, R2 and R3 are as defined in the description are highly suitable for use as biocides for protecting plants and industrial materials.

3-NITROISOXAZOLES AND THEIR USE IN THE PROTECTION OF MATERIALS

The 3-nitroisoxazoles of the formula (I) in which R1 and R2 are each as defined in the description, some of which are known, are highly suitable for use as biocides for protecting industrial materials.

O-aryl dithiazole dioxides

The invention relates to new O-aryldithiazole dioxides, to two processes for their preparation, and to their use as pesticides in crop protection and in the protection of materials.

Arylthio-dithiazindioxides and their use as pesticides

PCT No. PCT/EP97/07242 Sec. 371 Date Jun. 23, 1999 Sec. 102(e) Date Jun. 23, 1999 PCT Filed Dec. 22, 1997 PCT Pub. No. WO98/29400 PCT Pub. Date Jul. 9, 1998The invention relates to novel S-aryl-dithiazine dioxides, to processes for their preparation and to the use in crop protection and in the protection of materials.

REACTION OF 1,3,2-OXAZABORINANES WITH ALDEHYDES

The reaction of 1,3,2-oxazaborinanes with aldehydes leads to the corresponding tetrahydro-1,3-oxazines.The proposed reaction mechanism involves a cyclic intermediate structure formed as a result of coordination of the carbonyl oxygen at the boron atom or nucleophilic attack by one of the heteroatoms of the ring at the carbon atom of the carbonyl group.Their relative contributions are determined by the nature of the aldehyde.

Synthesis of aldehydes and products of such synthesis

The disclosure describes the production of complex aliphatic, unsaturated and cycloalkane aldehydes utilizing heterocyclic ring compounds, such as oxazines, particularly dihydro-1,3-oxazines. The oxazines are treated with an alkali metal-alkane compound, such as butyl lithium in the presence of an organic solvent at subzero temperature to form an anion of the oxazine. This anion is then alkylated in the anhydrous reaction mixture by introduction of a suitable halide, epoxide or ketone while still at a subzero temperature and mixture is permitted to warm up to room temperature, following which the reaction mixture is acidified, as with hydrochloric acid to pH 2 to 3, extracted and then made basic, as with caustic alkali with cooling. The reaction mixture is then extracted, as with ether, to produce after evaporation the alkylated dihydro-1,3-oxazine. The alkylated dihydro-1,3-oxazine is then reacted with an alkali metal or sodium borohydride or borodeuteride or borotritide, with cooling to subzero temperatures at about a neutral pH and then transferred into a basic aqueous environment following extraction of the aqueous layer with an organic solvent, such as ether, to give a tetrahydro-1,3-oxazine. This compound may then be converted to the aldehyde desired by steam distillation or by hydrolysis in the presence of a dilute or weak acid, such as hydrochloric or oxalic acid. The aldehydes may then be extracted. These aldehydes are useful as components or intermediates in flavoring or perfumes, in insect attractants and repellants, and in pharmaceuticals.