145615-35-6

Basic information

• Product Name: metronidazole glycyl phenylalaninate hydrochloride
• Synonyms: metronidazole glycyl phenylalaninate hydrochloride
• CAS NO: 145615-35-6
• Molecular Weight: 411.845
• Mol File: 145615-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: metronidazole glycyl phenylalaninate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: metronidazole glycyl phenylalaninate hydrochloride(145615-35-6)
• EPA Substance Registry System: metronidazole glycyl phenylalaninate hydrochloride(145615-35-6)

Safety Data

• Hazardous Substances Data: 145615-35-6(Hazardous Substances Data)

Upstream product

• 443-48-1 metronidazole 
• 4530-37-4 N-t-butyloxycarbonylglycyl-L-phenylalanine 

Downstream Products

• 3321-03-7 Gly-Phe-OH 
• 443-48-1 metronidazole 
• 5037-75-2 cyclo(Gly-Phe) 

Relevant articles and documents

SYNTHESIS OF DIPEPTIDE ESTERS OF METRONIDAZOLE AND EVALUATION OF THEIR HYDROLYTIC STABILITY

Amino acid and dipeptide esters of metronidazole were synthesized and evaluated on their hydrolytic stability in various buffers and culture media.The hydrolytic susceptibility of the different esters was minimal in the pH range 3-5.In the alkaline region, pH 6.5-8, the half-lifes were of the order of 1-6.6 hrs.At alkaline pH the dipeptide esters were more susceptible towards hydrolysis.At pH 8.8 the observed half-life for the gly-gly and the gly-phe esters was 0.2 h, whereas for the gly and the phe ester it was 1.1 h, respectively 2.7 h.It was demonstrated that the increased rate of hydrolysis for the dipeptide esters was due to an intramolecular aminolysis with the formation of a diketopiperazine accompanied by the release of free metronidazole.