14563-40-7

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 543-20-4 succinoyl dichloride 
• 1490-25-1 succinic acid monomethylester chloride 
• 5333-34-6 3-(3,4-dimethoxybenzoyl)propionic acid 
• 77-78-1 dimethyl sulfate 
• 186581-53-3 diazomethane 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 

Downstream Products

• 39499-66-6 6-(3,4-dimethoxy-phenyl)-2,3,4,5-tetrahydropyridazin-3-one 
• 443920-29-4 methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate 
• 112068-07-2 trans-(S,S)-2-(2-naphthyl)-5-(3,4-dimethoxyphenyl)tetrahydrofuran 
• 112068-05-0 (2S,5S)-2,5-Bis-(3,4-dimethoxy-phenyl)-tetrahydro-furan 
• 112022-85-2 (R)-5-(3,4-Dimethoxy-phenyl)-dihydro-furan-2-one 
• 51686-49-8 methyl 4-(3,4-dimethoxyphenyl)butanoate 
• 80937-21-9 (E)-methyl 4-(3,4-dimethoxyphenyl)-4-oxobut-2-enoate 
• 87364-88-3 6-(2-acetylamino-4,5-dimethoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone 
• 87374-67-2 4-(4,5-Dimethoxy-2-nitro-phenyl)-4-oxo-butyric acid ethyl ester 
• 87364-86-1 6-(4,5-dimethoxy-2-nitrophenyl)-4,5-dihydro-3(2H)-pyridazinone 
• 87364-87-2 6-(2-amino-4,5-dimethoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone 
• 87364-84-9 2-(4,5-dimethoxy-2-nitrobenzoyl)propionic acid 
• 87364-85-0 ethyl 2-(2-amino-4,5-dimethoxybenzoyl)propionate 
• 590418-56-7 methyl 4-(3,4-dimethoxyphenyl)-3-hydroxymethylbutanoate 

Relevant academic research and scientific papers

Synthesis of Medium-Ring-Sized Benzolactams by Using Strong Electrophiles and Quantitative Evaluation of Ring-Size Dependency of the Cyclization Reaction Rate

Benzolactams with medium-sized rings were synthesized via the electrophilic aromatic substitution reaction of carbamoyl cations (R1R2N+═C═O) in good to high yields without dilution. These reactions were utilized to quantitatively examine the extent of retardation of medium-sized ring formation, compared to five- or six-membered ring formation. The order of reaction rates of formation of cyclic benzolactams is six- > five- > seven- > eight- > nine-membered ring at 25 °C. The present reaction provides a route to eight- A nd nine-membered benzolactams.

Novel chemo-enzymatic process for the preparation of opticaly enriched beta-benzyl-gamma-butyrolactones

The present invention relates to a novel process for the preparation of optically enriched substituted R(+)β-benzyl-γ-butyrolactones of the general formula 1, 1wherein, R1 and R2 independently represent the following groups, R1=R2=H, OH, —OCnH2n+1 (n=1 to 8), NH2, and/or CF3, R1 and R2 together represents —O(CH2)mO— where m=2 to 4.

New chemo and chemo-enzymatic synthesis of β-benzyl-γ-butyrolactones

β-Benzyl-γ-butyrolactones, important intermediates for the synthesis of butyrolactone lignans, have been synthesized by a new route involving preparation of α-β-unsaturated formyl esters. The formyl esters can easily be converted into the desired butyrolactones either through chemical transformations or by enzymatic methods.

Syntheses and antiinflammatory activity of some 6-aryl-2,3,4,5-tetrahydro-3-pyridazinones

6-Aryl-2, 3, 4, 5-tetrahydro-3-pyridazinones (2c-22c) are obtained by dehydrocyclisation of various hydrazides formed by the reaction of appropriate methyl β-aroylpropionate and hydrazine hydrate in the presence of anhydrous sodium acetate. They show promising antiinflammatory activity during their evaluation by carrageenin induced paw edema test in rats.

ELECTRON DEFICIENT HETEROAROMATIC AMMONIOAMIDATES, XXIII. HETEROAROMATIC AMMONIOAMIDATES WITH BRIDGE-HEAD ammonium-NITROGEN

Two novel type heteroaromatic ammonioamidates of the general structure 2 with bridge-head ammonium-nitrogen, and the ammonium and amidate nitrogen as well as the amidate carbon atoms incorporated into a ring, viz. the angularly condensed dihydropyridazinoquinazoliniumolates 4 and 5 have been synthesized by cyclization of the dihydropyridazinone 15 and the aminoquinazolinium derivative 17, respectively.Cyclization of the 2-(methoxycarbonylalkyl)-3-quinazolinoamides 30 and 31 to furnish the linearly anellated type 2 compounds, 7 and 8, could not be brought about.The azides 24 and 36A did not cyclize with elimination of nitrogen to furnish compounds 5 or 6 and 9, respectively; instead, they reacted as acylating agents to give the diacylhydrazines 25 and 37, respectively.In contrast to the type 38a-38c quinazolinoamidates, compound 4 proved stable to Pyrex-filtered light.