145631-03-4

Basic information

• Product Name: (3S)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]carbamate
• Synonyms: (3S)-tetrahydrofuran-3-yl [(2S,3S,5R)-5-benzyl-3-hydroxy-6-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-6-oxo-1-phenylhexan-2-yl]carbamate; carbamic acid, N-[(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl]-, (3S)-tetrahydro-3-furanyl ester
• CAS NO: 145631-03-4
• Molecular Formula: C₃₃H₃₈N₂O₆
• Molecular Weight: 558.6646
• Mol File: 145631-03-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 841.8°C at 760 mmHg
• Flash Point: 462.9°C
• Density: 1.28g/cm³
• Vapor Pressure: 4.27E-30mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: (3S)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]carbamate(145631-03-4)
• EPA Substance Registry System: (3S)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]carbamate(145631-03-4)

Safety Data

• Hazardous Substances Data: 145631-03-4(Hazardous Substances Data)

Usage

Description

(3S)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino-5-oxopentyl]carbamate is a complex organic molecule characterized by a tetrahydrofuran ring and multiple functional groups, including a carbamate, dibenzyl, and several hydroxy and amino groups. (3S)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino-5-oxopentyl]carbamate exhibits stereochemistry with specific configurations at the tetrahydrofuran, dibenzyl, and hydroxy groups, which may contribute to its potential applications in medicinal chemistry.

Uses

Used in Pharmaceutical Development:
(3S)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino-5-oxopentyl]carbamate is used as a potential candidate in the pharmaceutical industry for the development of new drugs. The presence of hydroxy and amino groups, which are common in drug molecules, suggests that this compound could be utilized in the synthesis of novel pharmaceutical compounds with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (3S)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino-5-oxopentyl]carbamate is used as a subject of study to explore its chemical properties, reactivity, and potential interactions with biological targets. Understanding these aspects can lead to the design of more effective drugs targeting specific diseases or conditions.

Upstream product

• 126456-36-8 L-685434 
• 138499-08-8 1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione 
• 160333-50-6 1-({[(3R)-tetrahydrofuran-3-yloxy]carbonyl}oxy)pyrrolidine-2,5-dione 

Relevant articles and documents

HIV protease inhibitors useful for the treatment of aids

Compounds of the form,ψ ψ A-G-Jψ ψ wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.ψ