145643-32-9Relevant academic research and scientific papers
Phenyl amidines derivatives useful as platelet aggregation inhibitors
-
, (2008/06/13)
This invention relates to phenyl amidine derivatives having the following formula STR1 or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phe
Platelet aggregation inhibitors
-
, (2008/06/13)
This invention relates to compounds having the following formula STR1 or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions including the compounds, and to a method of inhi
Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Arg-guanidine of RGDX mimetics and the platelet GP IIb-IIIa receptor
Zablocki,Miyano,Garland,Pireh,Schretzman,Rao,Lindmark,Panzer-Knodle,Nicholson,Taite,Salyers,King,Campion,Feigen
, p. 1811 - 1819 (2007/10/02)
Peptide mimetics of the RGDF sequence in which Arg-Gly has been replaced with 5-(4-amidinophenyl)pentanoyl mimetic has led to a 1000-fold increase in inhibitory potency over the natural RGDF ligand. The guanidine residue of the arginine may be involved in
Peptide mimetic compounds useful as platelet aggregation inhibitors
-
, (2008/06/13)
This invention relates to having the following formula STR1 or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
Platelet aggregation inhibitors
-
, (2008/06/13)
This invention relates to compounds having the following formula STR1 or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions including the compounds and to a method of inhib
