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2-(N-benzyl-2-((1'R,4a'S,5S,8a'S)-2',5,5',5',8a'-pentamethyl-4,4a',5,5',6',7',8',8a'-octahydro-3H,4'H-spiro[furan-2,1'-naphthalene]-5-yl)acetamido)-N-tert-butyl-2-methylpropanamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1456515-49-3

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1456515-49-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1456515-49-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,6,5,1 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1456515-49:
(9*1)+(8*4)+(7*5)+(6*6)+(5*5)+(4*1)+(3*5)+(2*4)+(1*9)=173
173 % 10 = 3
So 1456515-49-3 is a valid CAS Registry Number.

1456515-49-3Downstream Products

1456515-49-3Relevant academic research and scientific papers

Derivatives of grindelic acid: From a non-active natural diterpene to synthetic antitumor derivatives

Reta, Guillermo F.,Chiaramello, Alejandra I.,Garcia, Celina,Leon, Leticia G.,Martin, Victor S.,Padron, Jose M.,Tonn, Carlos E.,Donadel, Osvaldo J.

, p. 28 - 38 (2013/10/01)

Using several reactions that include homologations and asymmetric epoxidations as well as Ugi and Huisgen couplings, we generated a small focused library of new derivatives from the labdane-type diterpene grindelic acid. These compounds were evaluated as cytotoxic agents against a panel of five human solid tumor cell lines (HBL-100, HeLa, SW1573, T-47D, and WiDr). The presence of the diamide functionalizations enhanced the cytotoxic effect. N-Benzyl-N-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)grindelicamide, proved to be the most active product in all cell lines tested, with values of 0.95 (±0.38) μM against HBL-100 cells. 2013 Elsevier Masson SAS. All rights reserved.

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