1456540-35-4Relevant academic research and scientific papers
Synthesis and photoinduced electron transfer in platinum(ii) bis(N-(4-ethynylphenyl)carbazole)bipyridine fullerene complexes
Lee, Sai-Ho,Chan, Chris Tsz-Leung,Wong, Keith Man-Chung,Lam, Wai Han,Kwok, Wai-Ming,Yam, Vivian Wing-Wah
, p. 17624 - 17634 (2014)
Platinum(ii) bis(N-(4-ethynylphenyl)carbazole)bipyridine fullerene complexes, (Cbz)2-Pt(bpy)-C60 and (tBuCbz)2-Pt(bpy)-C60, were synthesized. Their photophysical properties were studied by electronic absorption and emission spectroscopy and the origin of the transitions was supported by computational studies. The electrochemical properties were also studied and the free energies for charge-separation and charge-recombination processes were evaluated. The photoinduced electron transfer reactions in the triads were investigated by femtosecond and nanosecond transient absorption spectroscopy. In dichloromethane, both triads undergo ultrafast charge separation from the 3MLCT/LLCT excited state within 300 fs to yield their respective triplet charge-separated (CS) states, namely (Cbz)2+-Pt(bpy)-C60- and (tBuCbz)2+-Pt(bpy)-C60-, and the CS states would undergo charge recombination to give the 3C60 state, which subsequently decays to the ground state in 22-28 μs. This journal is
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists
Sheppeck II, James E.,Gilmore, John L.,Xiao, Hai-Yun,Dhar, T.G. Murali,Nirschl, David,Doweyko, Arthur M.,Sack, Jack S.,Corbett, Martin J.,Malley, Mary F.,Gougoutas, Jack Z.,McKay, Lorraine,Cunningham, Mark D.,Habte, Sium F.,Dodd, John H.,Nadler, Steven G.,Somerville, John E.,Barrish, Joel C.
, p. 5442 - 5447 (2013/09/23)
Modification of a phenolic lead structure based on lessons learned from increasing the potency of steroidal glucocorticoid agonists lead to the discovery of exceptionally potent, nonsteroidal, indazole GR agonists. SAR was developed to achieve good selectivity against other nuclear hormone receptors with the ultimate goal of achieving a dissociated GR agonist as measured by human in vitro assays. The specific interactions by which this class of compounds inhibits GR was elucidated by solving an X-ray co-crystal structure.
