145655-08-9Relevant academic research and scientific papers
Thiazole-Based Stereoselective Routes to Leucine and Phenylalanine Hydroxyethylene Dipeptide Isostere Inhibitors of Renin and HIV-1 Aspartic Protease
Dondoni, Alessandro,Perrone, Daniela,Semola, M. Teresa
, p. 7927 - 7933 (2007/10/03)
A new synthesis of hydroxyethylene dipeptide isosteres for Leu-Leu and Phe-Phe in their γ-lactone form 1a and 1b employing β-amino-α-hydroxy aldehydes with singly and doubly protected nitrogen has been developed.These key intermediates, which are availabl
Homologation of L-phenylalanine to ketomethylene and hydroxyethylene dipeptide isosteres via 2-thiazolyl amino ketone intermediate
Dondoni, Alessandro,Perrone, Daniela
, p. 7259 - 7262 (2007/10/02)
A highly efficient route is presented for the synthesis of N-protected isosteric dipeptides Pheψ[COCH2]Gly and Pheψ[CH(OH)CH2]Phe from L-phenylalanine through 2-thiazolyl α-amino ketone and δ-amino-γ-hydroxy-(E)-α,β-enoate derivative
