145655-33-0Relevant articles and documents
Access to Multisubstituted 2(5 H)-Furanones Using Hydrogen Bonding-Promoted Ring-Closing Metathesis and Polyamine Workup
Tan, Kai,Yan, Huan,Lu, Pengbo,Liu, Yuehui,Ji, Ruigeng,Liu, Zhongxian,Li, Ya-Min,Yu, Fu-Chao,Shen, Yuehai
, (2019)
Structurally complex 2(5H)-furanones are potentially challenging targets for ring-closing metathesis (RCM). A hydrogen bonding-guided RCM strategy was developed in this study to provide 3-substituted and 3,4-disubstituted 2(5H)-furanones in moderate to high yields with broad functional group tolerance. A workup procedure using ethylenediamine-derived polyamines such as tetraethylenepentylamine was also established to effectively remove Ru residues in products.