1456616-06-0Relevant academic research and scientific papers
Cu(i)-mediated 18F-trifluoromethylation of arenes: Rapid synthesis of 18F-labeled trifluoromethyl arenes
Rühl,Rafique,Lien,Riss
supporting information, p. 6056 - 6059 (2014/05/20)
This report is concerned with an efficient, CuI-mediated method for the radiosynthesis of [18F]trifluoromethyl arenes, abundant motifs in small molecule drug candidates and potential radiotracers for positron emission tomography. Thr
A broadly applicable [ 18 F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging
Huiban, Mickael,Tredwell, Matthew,Mizuta, Satoshi,Wan, Zehong,Zhang, Xiaomin,Collier, Thomas Lee,Gouverneur, Veronique,Passchier, Jan
, p. 941 - 944 (2013/12/04)
Molecules labelled with the unnatural isotope fluorine-18 are used for positron emission tomography. Currently, this molecular imaging technology is not exploited at its full potential because many 18 F-labelled probes are inaccessible or notoriously difficult to produce. Typical challenges associated with 18 F radiochemistry are the short half-life of 18 F (a high-priority demand for general methods allowing access to [ 18 F]CF 3 -substituted molecules for application in pharmaceutical discovery programmes. We report the development of a process for the late-stage [ 18 F]trifluoromethylation of (hetero)arenes from [ 18 F]fluoride using commercially available reagents and (hetero)aryl iodides. This [ 18 F]CuCF 3 -based protocol benefits from a large substrate scope and is characterized by its operational simplicity.
