1456728-68-9

Upstream product

• 100-52-7 benzaldehyde 
• 495-48-7 azoxybenzene 
• 100-51-6 benzyl alcohol 
• 103-50-4 dibenzyl ether 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 54184-69-9 2,3-diphenyl-2H-indazole 

Relevant academic research and scientific papers

Merging Visible-Light Photocatalysis and Palladium Catalysis for C-H Acylation of Azo- and Azoxybenzenes with α-Keto Acids

An efficient C-H acylation of azo- and azoxybenzenes with α-keto acids has been developed by a combination of palladium catalysis and visible-light photoredox catalysis at room temperature under 1.5 W blue LED irradiation. This method tolerates a variety of disubstituted azo- and azoxybenzenes, as well as α-keto acids regardless of the nature of the substituents. A number of aryl ketones were obtained in good yields under mild reaction conditions.

Direct Access to Acylated Azobenzenes and Amide Compounds by Reaction of Azoarenes with Benzylic Ethers as Acyl Equivalents

Described herein is the use of N=N double bond of azobenzene as both directing group and radical acceptor in one-reaction protocol for the first time. An efficient pathway for the Pd-catalyzed regiospecific ortho-acylation of azoarenes using benzylic ethers as acyl equivalents has been achieved. In the absence of palladium catalyst, amide compounds were formed by the reaction of azoarenes with benzylic ethers under certain conditions. Various mono-acylazobenzene and amide compounds were obtained in good yields (35 examples). The mono-acylated products and amide products could be easily controlled by palladium catalyst.

Palladium-catalyzed regio-selective oxidative C-H bond acylation of azoxybenzenes with alcohols

A palladium-catalyzed regio-selective acylation of C-H bonds of azoxybenzenes with alcohols was developed using tert-butyl hydroperoxide (TBHP) as an oxidant. Alcohol derivatives can act as effective acyl precursors in situ, which are less toxic, inexpensive, stable, and commercially available. These transformations proceeded smoothly and could tolerate a variety of functional groups. This journal is

Palladium-catalyzed regioselective ortho-acylation of azoxybenzenes with aldehyde derivatives

An efficient strategy for the regioselective ortho-acylation of azoxybenzenes with various aldehydes in the presence of palladium catalysts has been developed and furnishes good to excellent yields. The reaction proceeds smoothly and can tolerate a variety of functional groups.

Unprecedented ortho-acylation of azoxybenzenes with α-oxocarboxylic acids by Pd-catalyzed C-H activation and decarboxylation

A palladium-catalyzed ortho-acylation reaction of azoxybenzenes with α-oxocarboxylic acids was developed in the presence of K2S 2O8. The established methodology provides a direct approach to obtain acylated azoxybenzenes in good yields.