25539-20-2

Basic information

• Product Name: 2-PHENOXY-TEREPHTHALIC ACID
• Synonyms: 2-PHENOXY-TEREPHTHALIC ACID
• CAS NO: 25539-20-2
• Molecular Formula: C₁₄H₁₀O₅
• Molecular Weight: 258.2262
• Mol File: 25539-20-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PHENOXY-TEREPHTHALIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENOXY-TEREPHTHALIC ACID(25539-20-2)
• EPA Substance Registry System: 2-PHENOXY-TEREPHTHALIC ACID(25539-20-2)

Safety Data

• Hazardous Substances Data: 25539-20-2(Hazardous Substances Data)

Upstream product

• 107412-82-8 2-phenoxy-4-methylbenzoic acid 
• 1456885-46-3 di-tert-butyl 2-bromoterephthalate 
• 108-95-2 phenol 
• 7697-25-8 2-chloro-4-methylbenzoic acid 
• 5162-82-3 3-chloro-4-methylbenzoic acid 
• 586-35-6 2-bromo-1,4-benzenedicarboxylic acid 
• 209461-56-3 4-methyl-3-phenoxybenzoic acid 
• 21423-81-4 3-chloro-4-methylbenzonitrile 
• 21423-84-7 2-chloro-4-methylbenzonitrile 

Relevant articles and documents

Small-molecule ligands of methyl-lysine binding proteins: Optimization of selectivity for L3MBTL3

Lysine methylation is a key epigenetic mark, the dysregulation of which is linked to many diseases. Small-molecule antagonism of methyl-lysine (Kme) binding proteins that recognize such epigenetic marks can improve our understanding of these regulatory mechanisms and potentially validate Kme binding proteins as drug-discovery targets. We previously reported the discovery of 1 (UNC1215), the first potent and selective small-molecule chemical probe of a methyl-lysine reader protein, L3MBTL3, which antagonizes the mono- and dimethyl-lysine reading function of L3MBTL3. The design, synthesis, and structure-activity relationship studies that led to the discovery of 1 are described herein. These efforts established the requirements for potent L3MBTL3 binding and enabled the design of novel antagonists, such as compound 2 (UNC1679), that maintain in vitro and cellular potency with improved selectivity against other MBT-containing proteins. The antagonists described were also found to effectively interact with unlabeled endogenous L3MBTL3 in cells.

Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity

The discovery of new non-nucleoside antiviral compounds is of significant and growing interest for treating herpes virus infections due to the emergence of nucleoside-resistant strains. Using a whole cell virus-induced cytopathogenic assay, we tested a se

Substituted xanthones as antimycobacterial agents*, part 1: Synthesis and assignment of 1H/13C NMR chemical shifts

A series of substituted xanthones was synthesized in order to prove the hypothesis that electron-withdrawing substituents enhance the antimycobacterial activity of these compounds, which is described by means of a QSAR equation with 13C NMR che