1456898-49-9Relevant academic research and scientific papers
Synthesis of novel coumarin derivatives and in vitro biological evaluation as potential ptp 1b inhibitors
Sun, Cheng,Peng, Chune,Wang, Jian,Wang, Quan,Liu, Wei,Zhou, Honggang,Yang, Cheng
, p. 1711 - 1726 (2013/09/12)
The aim of protein tyrosine phosphatase 1B (PTP 1B) inhibitors is to develop effective drug for diabetes and obesity. Coumarin becomes as a good skeleton, and is often applied in drug design and synthesis. In this paper, we have synthesized a series of novel coumarin derivatives to be as potential PTP 1B inhibitors. The inhibition rate of compound 9 was more than 80%, and the IC50 value was 49.2 μM, which would be considered for further study.
