20862-58-2Relevant academic research and scientific papers
Synthesis of novel coumarin derivatives and in vitro biological evaluation as potential ptp 1b inhibitors
Sun, Cheng,Peng, Chune,Wang, Jian,Wang, Quan,Liu, Wei,Zhou, Honggang,Yang, Cheng
, p. 1711 - 1726 (2013/09/12)
The aim of protein tyrosine phosphatase 1B (PTP 1B) inhibitors is to develop effective drug for diabetes and obesity. Coumarin becomes as a good skeleton, and is often applied in drug design and synthesis. In this paper, we have synthesized a series of novel coumarin derivatives to be as potential PTP 1B inhibitors. The inhibition rate of compound 9 was more than 80%, and the IC50 value was 49.2 μM, which would be considered for further study.
Microwave assisted one pot synthesis of 7-substituted 2-(2-oxo-2H-chromen-3-yl)acetic acids as precursors of new anti-tumour compounds
Kovacova, Silvia,Kovacikova, Lucia,Lacova, Margita,Bohac, Andrej,Salisova, Marta
experimental part, p. 806 - 811 (2011/11/06)
Perkin condensation with subsequent intramolecular lactonisation as one pot syntheses of 2-(2-oxo-2H-chromen-3-yl)acetic acids VIIa-Xa has been studied. The required acids VIIa-Xa were prepared as precursors of recently discovered compounds possessing antineoplastic activities. Syntheses of VIIa-Xa were carried out using para substituted 2-hydroxybenzaldehydes II-VI, succinic acid anhydride, sodium succinate under thermal or microwave conditions. Significant shortening of the reaction time under microwave irradiation was observed (18-50 min instead of 1.5-5 h of heating). Microwave assisted reactions proceeded more smoothly to give higher yield of the required products VIIa-Xa (31-61 %) compared to those under classical thermal conditions e.g. 21.8 % for IXa (Hurenkamp et al., 2007). Seven reaction by-products were isolated and determined as 2H,2′H-3,3′-bichromene-2,2′-diones VIIb-Xb and (E)-3-(2-hydroxystyryl)-2H-chromen-2-ones VIIc-IXc.
Synthesis and photoinduced fluorescence of 3-(2-hetarylethenyl)chromen-2- ones
Bochkov,Yarovenko,Krayushkin,Chibisova,Valova,Barachevskii,Traven',Beletskaya
experimental part, p. 595 - 601 (2009/04/11)
3-(2-Hetarylethenyl)chromen-2-ones were synthesized for the first time, following two different schemes, and their spectral and photochemical properties were studied. The title compounds were found to undergo both reversible and irreversible photoinduced
Snythesis of 3-Styrylcoumarins from Coumarin-3-acetic Acids and 3-Phenacylcoumarins
Chodankar, N. K.,Joshi, S. D.,Sequeria, S.,Seshadri, S.
, p. 427 - 430 (2007/10/02)
The hitherto unknown 3-styrylcoumarin system has been synthesised by two routes.In the first approach, coumarin-3-acetic acids are reacted with aromatic aldehydes to yield directly the 3-styrylcoumarins.The synthesis is limited by the difficulty in obtaining coumarin-3-acetic acids in good yields.The second approach utilises 3-phenacylcoumarins which are reduced to the carbinols and subsequently dehydrated to the corresponding 3-styrylcoumarins.The fluorescence of these compounds and their application to polyester fibre have been studied.
