145744-12-3

Upstream product

• 2562-37-0 1-nitrocyclohexene 
• 120882-38-4 N,N-Diethyl-4-<(tert-butyldimethylsilyl)oxy>-1,3-benzodioxole-5-carboxamide 
• 94-53-1 Piperonylic acid 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 
• 120882-37-3 N,N-diethyl-4-hydroxy-1,3-benzodioxole-5-carboxamide 
• 15777-86-3 N,N-diethylbenzo[d][1,3]dioxole-5-carboxamide 
• 145744-12-3 4-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-cyclohexyl)-benzo[1,3]dioxole-5-carboxylic acid diethylamide 

Downstream Products

• 145744-12-3 4-(tert-Butyl-dimethyl-silanyloxy)-6-((1S,2R)-2-nitro-cyclohexyl)-benzo[1,3]dioxole-5-carboxylic acid diethylamide 

Relevant academic research and scientific papers

Synthesis of pancratistatin models

Two model syntheses for the phenanthridone core of the cytotoxic alkaloid pancratistatin are reported. The key maneuver in these syntheses is 1,4-addition of an ortho-lithiated benzamide derivative to 1-nitrocyclohexene. The resulting 2-aryl-1-nitrocyclohexanes (6 and 11) are further transformed into the pancratistatin models 2 and 3.