15777-86-3

Basic information

• Product Name: N,N-diethyl-1,3-benzodioxole-5-carboxamide
• Synonyms: 1,3-benzodioxole-5-carboxamide, N,N-diethyl-; Benzo[1,3]dioxole-5-carboxylic acid diethylamide; N,N-Diethyl-1,3-benzodioxole-5-carboxamide; Piperonylamide, N,N-diethyl-
• CAS NO: 15777-86-3
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• Mol File: 15777-86-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 374.2°C at 760 mmHg
• Flash Point: 180.1°C
• Density: 1.171g/cm³
• Vapor Pressure: 8.5E-06mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: N,N-diethyl-1,3-benzodioxole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-1,3-benzodioxole-5-carboxamide(15777-86-3)
• EPA Substance Registry System: N,N-diethyl-1,3-benzodioxole-5-carboxamide(15777-86-3)

Safety Data

• Hazardous Substances Data: 15777-86-3(Hazardous Substances Data)

Upstream product

• 37673-00-0 benzo[1,3]dioxol-5-yl-diethylamino-acetonitrile 
• 120-57-0 piperonal 
• 109-89-7 diethylamine 
• 20850-43-5 5-(chloromethyl)-1,3-benzodioxole 
• 94-53-1 Piperonylic acid 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 

Downstream Products

• 1321616-96-9 N,N-diethyl-6-(4-methoxybenzoyl)benzo-[1,3]-dioxole-5-carboxamide 
• 130861-31-3 (2R,3S,4S,4aR,11bS)-5-Benzyl-2,3,4-tris-benzyloxy-3,4,4a,11b-tetrahydro-2H,5H-[1,3]dioxolo[4,5-j]phenanthridine-1,6-dione 
• 130861-27-7 (1S,2S,3S,4S,4aR,11bS)-5-Benzyl-2,3,4-tris-benzyloxy-1-hydroxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one 
• 130861-30-2 (+)-tetrabenzyllycoricidine 
• 130861-22-2 4-Trimethylsilanyl-6-((3S,4R,5S)-3,4,5-tris-benzyloxy-2-hydroxy-hept-6-enyl)-benzo[1,3]dioxole-5-carboxylic acid diethylamide 
• 130861-24-4 6-((3R,4R,5S)-3,4,5-Tris-benzyloxy-2-oxo-hept-6-enyl)-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 130861-23-3 7-((1S,2R,3S)-1,2,3-Tris-benzyloxy-pent-4-enyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isochromen-5-one 
• 145744-12-3 4-(tert-Butyl-dimethyl-silanyloxy)-6-((1S,2R)-2-nitro-cyclohexyl)-benzo[1,3]dioxole-5-carboxylic acid diethylamide 
• 145744-12-3 4-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-cyclohexyl)-benzo[1,3]dioxole-5-carboxylic acid diethylamide 
• 163082-18-6 (3'aS,4'R,5'R,7'aR)-7-Ethoxymethoxy-2',2'-dimethyl-4'-(toluene-4-sulfonylamino)-3'a,4',5',7'a-tetrahydro-[5,5']bi[benzo[1,3]dioxolyl]-6-carboxylic acid diethylamide 
• 105259-54-9 7-Phenylsulfanyl-naphtho[1,2-d][1,3]dioxole-6,9-dione 

Relevant articles and documents

Concise synthesis of the bioactive natural polyhydroxynaphthoate parvinaphthol B via Hauser-Kraus annulation

Herein, we describe the first total synthesis of parvinaphthol B, a polyhydroxynaphthoate derived from the root of Pentas parvifolia which exhibits cytotoxic effects against the TNBC cell line. The key feature of the synthesis involves a Hauser-Kraus annulation to provide the polyhydroxynaphthoate skeleton. The synthesis requires only six linear steps and afforded the product in 26.5% overall yield, thus representing a simple method for the further preparation of analogs and biological studies.

Branch-selective, Iridium-catalyzed hydroarylation of monosubstituted alkenes via a cooperative destabilization strategy

Highly branch-selective, carbonyl-directed hydroarylations of monosubstituted alkenes are described. The chemistry relies upon a cationic Ir(I) catalyst modified with an electron deficient, wide bite angle bisphosphine ligand. This work provides a regioisomeric alternative to the Murai hydroarylation protocol.

A chemoenzymatic total synthesis of ent-narciclasine

The synthesis of the title compound [(-)-1] has been achieved, for the first time, by reacting the aryl boronic acid ester 4 with the aminoconduritol derivative 6 under Suzuki-Miyaura cross-coupling conditions then subjecting the product phenanthridinone