145798-29-4Relevant academic research and scientific papers
Copper-Catalyzed Enantioselective Allylic Alkylation with a γ-Butyrolactone-Derived Silyl Ketene Acetal
Jette, Carina I.,Tong, Z. Jaron,Hadt, Ryan G.,Stoltz, Brian M.
, p. 2033 - 2038 (2020)
Herein, we report a Cu-catalyzed enantioselective allylic alkylation using a γ-butyrolactone-derived silyl ketene acetal. Critical to the development of this work was the identification of a novel mono-picolinamide ligand with the appropriate steric and electronic properties to afford the desired products in high yield (up to 96 %) and high ee (up to 95 %). Aryl, aliphatic, and unsubstituted allylic chlorides bearing a broad range of functionality are well-tolerated. Spectroscopic studies reveal that a CuI species is likely the active catalyst, and DFT calculations suggest ligand sterics play an important role in determining Cu coordination and thus catalyst geometry.
Substituted azabicycloheptane derivatives, their preparation and use
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, (2008/06/13)
Novel 3-azabicyclo[3.2.0]heptane derivatives of the formula STR1 in which R1 and R2 have the meanings stated in the description, and their preparation are described. The substances are intermediates for the preparation of drugs.
