145827-24-3Relevant articles and documents
Synthesis of diacylglycerol analogues as potential second messenger antagonists and inhibitors of protein kinase C
Briggs, Josie C.,Haines, Alan H.,Taylor, Richard J. K.,Dawson, Alan P.,Gibson, I.,et al.
, p. 23 - 36 (1992)
A series of analogues of diacylglycerol has been prepared and tested as inhibitors of protein kinase C (PKC).The diketone analogues, 10-hydroxymethyl-8,13-eicosanedione (24), 10-acetoxymethyl-8,13-eicosanedione (25), and 10-methoxymethyl-8,13-eicosanedione (26) each inhibited PKC activated by 2-O-acetyl-1-O-oleoylglycerol.Compound 24 was the most effective inhibitor of the growth of MR4 and HT29 cells in culture, and 26 was more effective than 24 against HL60 cells.
