145827-23-2Relevant academic research and scientific papers
A selective resin for trans-diequatorial-1,2-diols
Lence, Emilio,Castedo, Luis,González-Bello, Concepción
scheme or table, p. 1795 - 1798 (2009/07/05)
A selective resin for linking trans-diequatorial-1,2-diols to solid support is described. This linking was carried out under mild and aprotic conditions involving the use of trimethylsilyl methyl ether in the presence of trimethylsilyl trifluoromethanesul
Synthesis of diacylglycerol analogues as potential second messenger antagonists and inhibitors of protein kinase C
Briggs, Josie C.,Haines, Alan H.,Taylor, Richard J. K.,Dawson, Alan P.,Gibson, I.,et al.
, p. 23 - 36 (2007/10/02)
A series of analogues of diacylglycerol has been prepared and tested as inhibitors of protein kinase C (PKC).The diketone analogues, 10-hydroxymethyl-8,13-eicosanedione (24), 10-acetoxymethyl-8,13-eicosanedione (25), and 10-methoxymethyl-8,13-eicosanedione (26) each inhibited PKC activated by 2-O-acetyl-1-O-oleoylglycerol.Compound 24 was the most effective inhibitor of the growth of MR4 and HT29 cells in culture, and 26 was more effective than 24 against HL60 cells.
Regiochemical Control of the Ring-Opening of 1,2-Epoxides by Means of Chelating Processes. 2. Synthesis and Reactions of the cis- and trans-Oxides of 4-cyclohexene, 3-Cyclohexenemethanol, and Methyl 3-Cyclohexenecarboxylate
Chini, Marco,Crotti, Paolo,Flippin, Lee A.,Macchia, Franco,Pineschi, Mauro
, p. 1405 - 1412 (2007/10/02)
The synthesis of the diastereoisomeric epoxides cis-1b-d and trans-2b-d and the products of their ring-opening by various nucleophiles are described.The results of the ring-openings of the trans-epoxides 2b-d can be rationalized by combining stereoelectro
