145873-44-5Relevant articles and documents
Sequential one-pot aldol reactions catalyzed by 2-deoxyribose-5-phosphate aldolase and fructose-1,6-diphosphate aldolase
Gijsen, Harrie J. M.,Wong, Chi-Huey
, p. 2947 - 2948 (1995)
-
Oxidative esterification of primary alcohols with TEMPO/CaCl2/Oxone under hydrous conditions
Hackbusch, Sven,Franz, Andreas H.
, p. 2873 - 2876 (2016/06/14)
Symmetric esters are important compounds in the chemical industry, which creates demand for simple and efficient synthetic routes. Oxidative esterification is a promising method to achieve these aims. Here, we show that TEMPO/CaCl2/Oxone forms a convenient catalytic system for the synthesis of the aforementioned symmetric esters from primary alcohols in a biphasic dichloromethane-water solvent mixture. The substrate scope of the reaction method is complementary to those previously published and the terminal oxidant appears to play an important role. In addition, the method is shown to oxidize thiols preferentially over alcohol functional groups to give disulfide-bridged compounds.
Process for the preparation of 3-hydroxytetrahydrofuran
-
Page column 13, (2008/06/13)
An industrial advantage process for producing high-purity 3-hydroxytetrahydrofuran easily and simply, which comprises reducing a 4-halo-3-hydroxybutyric acid ester (1) with a boron hydride compound and/or an aluminum hydride compound as a reducing agent in an organic solvent immiscible with water; treating the reaction mixture with an acid and water to thereby effect conversion to the corresponding 4-halo-1,3-butanediol and at the same time giving an aqueous solution containing said compound; carrying out the cyclization reaction of the 4-halo-1,3-butanediol in said aqueous solution; extracting the resulting 3-hydroxytetrahydrofuran from the 3-hydroxytetrahydrofuran-containing aqueous solution using an organic solvent immiscible with water; and isolating the 3-hydroxytetrahydrofuran by concentration and/or distillation of the solution obtained.