145902-33-6

Upstream product

• 647852-19-5 (S)-2-Oxo-4-phenyl-3-(trityl-amino)-butyric acid methyl ester 
• 820993-99-5 N-(tert-butyloxycarbonyl)-(2RS,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 148692-40-4 methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate 
• 647852-04-8 [(S)-2-Oxo-4-phenyl-3-(trityl-amino)-butyl]-phosphonic acid dimethyl ester 
• 647852-10-6 (E)-(S)-1,5-Diphenyl-4-(trityl-amino)-pent-1-en-3-one 
• 18598-80-6 methyl N-trityl-(S)-phenylalaninate 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Relevant academic research and scientific papers

A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates

Practical synthetic routes to β-amino-α-hydroxy carboxylates (AHC) have been developed from amino acids. Reduction of β-amino-α- keto esters 6 with NaBH4 was found to give anti-AHCs 7 in high de, which were efficiently converted to the corresponding syn-AHCs 8 via oxazolidine ring 10 formation.

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

Leukotriene A4 hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B4 is an inflammatory mediator, it is of interest to develop selective inh