148692-40-4

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 820993-99-5 N-(tert-butyloxycarbonyl)-(2RS,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 67-56-1 methanol 

Downstream Products

• 145902-33-6 (S)-3-Amino-2-oxo-4-phenyl-butyric acid methyl ester; hydrochloride 
• 820993-99-5 N-(tert-butyloxycarbonyl)-(2RS,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 116565-03-8 N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester 

Relevant academic research and scientific papers

First Synthesis of Enantiomerically Pure N-Protected β-Amino-α-Keto Esters from α-Amino Acids and Dipeptides

A racemization-free route from N-protected α-amino acids and dipeptides to N-protected β-amino-α-keto esters is described, involving the sequence: diazoketone formation, Wolff rearrangement in methanol, diazo transfer, and oxidation with dimethyldioxirane.

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

Leukotriene A4 hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B4 is an inflammatory mediator, it is of interest to develop selective inh