14593-25-0

Basic information

• Product Name: 4-[1-Chloro-2-(methylamino)ethyl]phenyl Acetate Hydrochloride
• Synonyms: 4-[1-Chloro-2-(methylamino)ethyl]phenyl Acetate Hydrochloride;Glucocorticoid Receptor Modulator, CpdA;4-(1-Chloro-2-(methylamino);phenyl acetate hydrochloride;4-[1-CHLORO-2-(METHYLAMINO)ETHYL]PHENYL ACETATE HCL
• CAS NO: 14593-25-0
• Molecular Formula: C₁₁H₁₄ClNO₂*ClH
• Molecular Weight: 264.1483
• Mol File: 14593-25-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 177-179 °C
• Boiling Point: 324.6°C at 760 mmHg
• Flash Point: 150.1°C
• Appearance: /
• Vapor Pressure: 0.000243mmHg at 25°C
• Storage Temp.: = -70C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-[1-Chloro-2-(methylamino)ethyl]phenyl Acetate Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[1-Chloro-2-(methylamino)ethyl]phenyl Acetate Hydrochloride(14593-25-0)
• EPA Substance Registry System: 4-[1-Chloro-2-(methylamino)ethyl]phenyl Acetate Hydrochloride(14593-25-0)

Safety Data

• Hazardous Substances Data: 14593-25-0(Hazardous Substances Data)

Usage

General Description

4-[1-Chloro-2-(methylamino)ethyl]phenyl Acetate Hydrochloride is a chemical compound that contains a phenyl group with an acetate group attached to it, as well as a chlorine atom and a methylamino group. The hydrochloride salt form of the compound indicates that it is in a salt form, which can affect its solubility and stability. This chemical may have uses in various industries, including pharmaceuticals, agriculture, and research, where it may be used as an intermediate in the synthesis of other compounds. It is important to handle and use this chemical with care, following proper safety protocols and regulations to avoid any potential hazards.

InChI:InChI=1/C11H14ClNO2.ClH/c1-8(14)15-10-5-3-9(4-6-10)11(12)7-13-2;/h3-6,11,13H,7H2,1-2H3;1H

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Relevant articles and documents

Mechanism for the stabilization in vivo of the aziridine precursor 2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride by serum proteins

Oral and intraperitoneal administration of 2-(4-acetoxyphenyl)-2-chloro-N-methylethylammonium chloride (Compound A), an analogue of phenyl aziridine precursors that occur in the shrub Salsola tuberculatiformis Botsch., had a contraceptive effect on female Wistar rats with a concomitant decrease in total body, uterus, and ovary mass and an increase in adrenal mass. Compound A elicited a Type II difference spectrum and inhibited the Type I deoxycorticosterone (DOC) induced difference spectrum of sheep adrenal cytochrome P450c11 in a manner similar to that of S2, a biologically active fraction isolated from S. tuberculatiformis. The effects of Compound A on the spectral properties of P450c11 were diminished with time in PBS. ELectrospray mass spectrometry (ES-MS) indicated that the rate of cyclization of Compound A to the corresponding aziridine followed a time course similar to the attenuation of cytochrome P450c11 inhibition. It was concluded that the aziridine precursor, Compound A, rather than aziridine itself, was the inhibiting agent of sheep adrenal P450c11. Addition of sheep and rat plasma prevented the attenuation of the effect of Compound A on the spectral properties of cytochrome P450c11. Subsequent ES-MS analysis indicated that Compound A was stabilized in plasma by sex hormone binding globulin and corticosteroid binding globulin. These results suggest a mechanism whereby natural plant products, which are highly reactive and unstable in vitro, can be stabilized by binding to plasma proteins, and so remain biologically active in vivo.